Reactome | Signaling by NOTCH2

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Signaling by NOTCH2 Show undefined attributes

compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:7660] nucleoplasm
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10730516
displayName	Signaling by NOTCH2
eventOf	[Pathway:R-XTR-157118] Signaling by NOTCH - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:20089] Notch signaling pathway
hasDiagram	true
hasEHLD	false
hasEvent	[Pathway:R-XTR-2979096] NOTCH2 Activation and Transmission of Signal to the Nucleus - Xenopus tropicalis [Pathway:R-XTR-2197563] NOTCH2 intracellular domain regulates transcription - Xenopus tropicalis
inferredFrom	[Pathway:R-HSA-1980145] Signaling by NOTCH2 - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	3
name	Signaling by NOTCH2
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-1980145
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-157118] Signaling by NOTCH
(inferredTo)	[Pathway:R-HSA-1980145] Signaling by NOTCH2
(hasEncapsulatedEvent)	[Pathway:R-XTR-1912422] Pre-NOTCH Expression and Processing

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