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Reaction
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Entries
SRC family kinases phosphorylate ERBB2
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authored
[InstanceEdit:1972351] Orlic-Milacic, M, 2011-11-04
catalystActivity
[CatalystActivity:1810443] protein tyrosine kinase activity of p-Y419/420/426-N-myristoyl-SRC/FYN/YES1 [plasma membrane]
catalystActivityReference
[CatalystActivityReference:9643483] protein tyrosine kinase activity of p-Y419/420/426-N-myristoyl-SRC/FYN/YES1 [plasma membrane] Loss of Hsp90 association up-regulates Src-dependent ErbB2 activity
category
transition
compartment
[Compartment:876] plasma membrane
[Compartment:70101] cytosol
[Compartment:984] extracellular region
created
[InstanceEdit:1963565] Orlic-Milacic, M, 2011-11-03
dbId
1963586
displayName
SRC family kinases phosphorylate ERBB2
edited
[InstanceEdit:1972360] D'Eustachio, P, 2011-11-07
eventOf
[Pathway:R-HSA-1227986] Signaling by ERBB2 - Homo sapiens
followingEvent
[Reaction:R-HSA-1963581] Trans-autophosphorylation of p-Y877-ERBB2 heterodimers - Homo sapiens
input
[SimpleEntity:R-ALL-113592] ATP [cytosol]
[DefinedSet:R-HSA-1963573] ERBB2 heterodimers [plasma membrane]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:1810436] Loss of Hsp90 association up-regulates Src-dependent ErbB2 activity
maxDepth
1
modified
[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name
SRC family kinases phosphorylate ERBB2
orthologousEvent
[Reaction:R-CEL-1963586] SRC family kinases phosphorylate ERBB2 - Caenorhabditis elegans
[Reaction:R-GGA-1963586] SRC family kinases phosphorylate ERBB2 - Gallus gallus
[Reaction:R-DRE-1963586] SRC family kinases phosphorylate ERBB2 - Danio rerio
[Reaction:R-SSC-1963586] SRC family kinases phosphorylate ERBB2 - Sus scrofa
[Reaction:R-BTA-1963586] SRC family kinases phosphorylate ERBB2 - Bos taurus
[Reaction:R-CFA-1963586] SRC family kinases phosphorylate ERBB2 - Canis familiaris
[Reaction:R-RNO-1963586] SRC family kinases phosphorylate ERBB2 - Rattus norvegicus
[Reaction:R-MMU-1963586] SRC family kinases phosphorylate ERBB2 - Mus musculus
output
[SimpleEntity:R-ALL-29370] ADP [cytosol]
[DefinedSet:R-HSA-1963584] p-Y877-ERBB2 heterodimers [plasma membrane]
precedingEvent
[Reaction:R-HSA-1963589] ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR, ERBB3 and ERBB4 - Homo sapiens
releaseDate
2011-12-06
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:1972347] Neckers, LM, 2011-11-11
[InstanceEdit:1972346] Xu, W, 2011-11-11
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-1963586
summation
[Summation:1963575] Dissociation of HSP90 from ERBB2 upon formation of ERBB2 het...
Referrals
(hasEvent)
[Pathway:R-HSA-1227986] Signaling by ERBB2
(precedingEvent)
[Reaction:R-HSA-1963581] Trans-autophosphorylation of p-Y877-ERBB2 heterodimers
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