SRC family kinases phosphorylate ERBB2

Stable Identifier
R-HSA-1963586
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Dissociation of HSP90 from ERBB2 upon formation of ERBB2 heterodimers (with either EGFR, ERBB3 or ERBB4) enables phosphorylation of ERBB2 on the tyrosine residue Y877, mediated by one of SRC family kinases - SRC, FYN or YES1. Although not a mandatory prerequisite of ERBB2 catalytic activity, the phosphorylation at Y877 significantly increases the kinase activity of ERBB2.

Literature References
PubMed ID Title Journal Year
17030621 Loss of Hsp90 association up-regulates Src-dependent ErbB2 activity Mol Cell Biol 2007
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of p-Y419/420/426-N-myristoyl-SRC/FYN/YES1 [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed