SRC family kinases phosphorylate ERBB2

Stable Identifier
R-HSA-1963586
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane, cytosol, extracellular region
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
SRC family kinases phosphorylate ERBB2
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Dissociation of HSP90 from ERBB2 upon formation of ERBB2 heterodimers (with either EGFR, ERBB3 or ERBB4) enables phosphorylation of ERBB2 on the tyrosine residue Y877, mediated by one of SRC family kinases - SRC, FYN or YES1. Although not a mandatory prerequisite of ERBB2 catalytic activity, the phosphorylation at Y877 significantly increases the kinase activity of ERBB2.

Literature References
PubMed ID Title Journal Year
17030621 Loss of Hsp90 association up-regulates Src-dependent ErbB2 activity

Yuan, X, Xiang, Z, Beebe, K, Neckers, LM, Xu, W

Mol Cell Biol 2007
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein tyrosine kinase activity of p-Y419/420/426-N-myristoyl-SRC/FYN/YES1 [plasma membrane]

Physical Entity
p-Y419/420/426-N-myristoyl-SRC/FYN/YES1 [plasma membrane] (Homo sapiens)
Activity
protein tyrosine kinase activity (GO:0004713)
Orthologous Events
SRC family kinases phosphorylate ERBB2 (Bos taurus)
SRC family kinases phosphorylate ERBB2 (Caenorhabditis elegans)
SRC family kinases phosphorylate ERBB2 (Canis familiaris)
SRC family kinases phosphorylate ERBB2 (Danio rerio)
SRC family kinases phosphorylate ERBB2 (Drosophila melanogaster)
SRC family kinases phosphorylate ERBB2 (Gallus gallus)
SRC family kinases phosphorylate ERBB2 (Mus musculus)
SRC family kinases phosphorylate ERBB2 (Rattus norvegicus)
SRC family kinases phosphorylate ERBB2 (Sus scrofa)
SRC family kinases phosphorylate ERBB2 (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2011-11-04)
Reviewed
Neckers, LM  (2011-11-11)
Xu, W  (2011-11-11)
Created
Orlic-Milacic, M  (2011-11-04)
Cite Us!