Reactome | botE LC cleaves target cell SNAP25

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botE LC cleaves target cell SNAP25 Show undefined attributes

authored	[InstanceEdit:194836] Krupa, S, Gopinathrao, G, 2006-06-15 10:36:11
catalystActivity	[CatalystActivity:194814] metalloendopeptidase activity of botE LC:Zn2+ [cytosol]
catalystActivityReference	[CatalystActivityReference:9643983] metalloendopeptidase activity of BoNT/E LC:Zn2+ [cytosol] Botulinum neurotoxins serotypes A and E cleave SNAP-25 at distinct COOH-terminal peptide bonds
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:194803] Gopinathrao, G, 2007-03-27 17:24:22
crossReference	[DatabaseIdentifier:12020820] Mondo:0005498
dbId	194800
deleted	[Deleted:5251002] Deletion of instance: 181546
disease	[Disease:3632909] botulism
displayName	botE LC cleaves target cell SNAP25
edited	[InstanceEdit:181692] Gopinathrao, G, 2006-06-15 22:12:29
eventOf	[Pathway:R-HSA-5250992] Toxicity of botulinum toxin type E (botE) - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-2029017] SNAP25 [plasma membrane]
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:181730] Proteolysis of SNAP-25 by types E and A botulinal neurotoxins [LiteratureReference:181764] Botulinum neurotoxins serotypes A and E cleave SNAP-25 at distinct COOH-terminal peptide bonds [LiteratureReference:5263580] Membrane fusion machinery: insights from synaptic proteins [LiteratureReference:379281] The synaptic vesicle cycle [LiteratureReference:181774] Proteolysis of SNAP-25 isoforms by botulinum neurotoxin types A, C, and E: domains and amino acid residues controlling the formation of enzyme-substrate complexes and cleavage
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	botE LC cleaves target cell SNAP25
output	[EntityWithAccessionedSequence:R-HSA-3004550] SNAP25(1-198) [plasma membrane] [EntityWithAccessionedSequence:R-HSA-5244501] SNAP25(199-206) [cytosol]
precedingEvent	[BlackBoxEvent:R-HSA-5244506] botE HC transports botE LC from target cell synaptic vesicle membrane into cytosol - Homo sapiens
relatedSpecies	[Species:168825] Clostridium botulinum
releaseDate	2007-08-21
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:201311] Ichtchenko, K, 2007-08-03 18:17:25 [InstanceEdit:5643756] Thirunavukkarasu, Nagarajan, Sharma, Shashi, 2014-11-17
revised	[InstanceEdit:5263589] D'Eustachio, Peter, 2014-02-10
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-194800
summation	[Summation:201308] Botulinum toxin type E light chain (botE LC), in the cytosol...
updateTrackers	[UpdateTracker:9788074] Update Tracker - [Reaction:194800] botE LC cleaves target cell SNAP25 - v44:[add_removeInput, add_removeOutput] [UpdateTracker:9786718] Update Tracker - [Reaction:194800] botE LC cleaves target cell SNAP25 - v48:[add_removeLiteratureReference, add_removeOutput, modifyText] [UpdateTracker:9786331] Update Tracker - [Reaction:194800] botE LC cleaves target cell SNAP25 - v50:[modifyText] [UpdateTracker:9776502] Update Tracker - [Reaction:194800] botE LC cleaves target cell SNAP25 - v75:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9788074] Update Tracker - [Reaction:194800] botE LC cleaves target cell SNAP25 - v44:[add_removeInput, add_removeOutput] [UpdateTracker:9786718] Update Tracker - [Reaction:194800] botE LC cleaves target cell SNAP25 - v48:[add_removeLiteratureReference, add_removeOutput, modifyText] [UpdateTracker:9786331] Update Tracker - [Reaction:194800] botE LC cleaves target cell SNAP25 - v50:[modifyText] [UpdateTracker:9776502] Update Tracker - [Reaction:194800] botE LC cleaves target cell SNAP25 - v75:[modifyText]
(replacementInstances)	[Deleted:5251002] Deletion of instance: 181546
(hasEvent)	[Pathway:R-HSA-5250992] Toxicity of botulinum toxin type E (botE)

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