Botulinum toxin type E light chain (botE LC), in the cytosol...

created [InstanceEdit:201316] Gopinathrao, G, 2007-08-03 18:19:30
dbId 201308
displayName Botulinum toxin type E light chain (botE LC), in the cytosol...
modified [InstanceEdit:9704403] D'Eustachio, Peter, 2020-10-08
schemaClass Summation
text Botulinum toxin type E light chain (botE LC), in the cytosol of a target cell, catalyzes the removal of a carboxyterminal peptide from synaptosomal-associated protein 25 (SNAP25). botE LC is a zinc metalloprotease (Binz et al. 1994; Schiavo et al. 1993; Vaidyanathan et al. 1999). SNAP25 is associated with the cytosolic face of the target cell plasma membrane where it forms part of a complex required for synaptic vesicle docking and exocytosis. Its cleavage by botulinum toxin blocks synaptic vesicle fusion with the plasma membrane and neurotransmitter release and in vivo leads to a long lasting flaccid paralysis (Sudhof et al, 1993; Sudhof 2004).
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