Reactome | CYP21A2 oxidises 17HPROG

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CYP21A2 oxidises 17HPROG Show undefined attributes

authored	[InstanceEdit:378946] Jassal, Bijay, 2008-10-01
catalystActivity	[CatalystActivity:194007] progesterone 21-hydroxylase activity of CYP21A2 [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:194008] Jassal, B, 2007-03-06 13:54:16
crossReference	[DatabaseIdentifier:9913420] RHEA:50309
dbId	193981
displayName	CYP21A2 oxidises 17HPROG
edited	[InstanceEdit:196368] Jassal, B, 2007-04-20 21:09:56
eventOf	[Pathway:R-HSA-194002] Glucocorticoid biosynthesis - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-194025] 11-deoxycortisol translocates to the mitochondrion - Homo sapiens
input	[SimpleEntity:R-ALL-193092] 17aHPROG [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29364] NADPH [cytosol] [SimpleEntity:R-ALL-29368] O2 [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:193989] Structure of human steroid 21-hydroxylase genes [LiteratureReference:193990] Molecular characterization of the HLA-linked steroid 21-hydroxylase B gene from an individual with congenital adrenal hyperplasia
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	CYP21A2 oxidises 17HPROG 17alpha-hydroxyprogesterone + O2 + reduced (NADPH--hemoprotein reductase) => 11-deoxycortisol + H(+) + H2O + oxidized (NADPH--hemoprotein reductase) Hydroxylation of 17-hydroxyprogesterone to form 11-deoxycortisol 17-hydroxyprogesterone + NADPH + H+ + O2 => 11-deoxycortisol + NADP+ + H2O
orthologousEvent	[Reaction:R-GGA-193981] CYP21A2 oxidises 17HPROG - Gallus gallus [Reaction:R-DRE-193981] CYP21A2 oxidises 17HPROG - Danio rerio [Reaction:R-SSC-193981] CYP21A2 oxidises 17HPROG - Sus scrofa [Reaction:R-BTA-193981] CYP21A2 oxidises 17HPROG - Bos taurus [Reaction:R-CFA-193981] CYP21A2 oxidises 17HPROG - Canis familiaris [Reaction:R-RNO-193981] CYP21A2 oxidises 17HPROG - Rattus norvegicus [Reaction:R-MMU-193981] CYP21A2 oxidises 17HPROG - Mus musculus
output	[SimpleEntity:R-ALL-193966] 11-deoxycortisol [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-29366] NADP+ [cytosol]
precedingEvent	[Reaction:R-HSA-193961] Pregn-5-ene-3,20-dione-17-ol isomerizes to 17-hydroxyprogesterone - Homo sapiens [Reaction:R-HSA-193072] CYP17A1 17-hydroxylates P4 to 17aHPROG - Homo sapiens
releaseDate	2007-05-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:196370] D'Eustachio, P, 2007-04-20 21:11:21
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-193981
summation	[Summation:193992] 17-Hydroxyprogesterone, NADPH + H+, and O2 react to form 11-...

Referrals

(hasEvent)	[Pathway:R-HSA-194002] Glucocorticoid biosynthesis
(precedingEvent)	[BlackBoxEvent:R-HSA-194025] 11-deoxycortisol translocates to the mitochondrion

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