Reactome | CYP21A2 oxidises 17HPROG

CYP21A2 oxidises 17HPROG

Stable Identifier

R-HSA-193981

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, endoplasmic reticulum membrane

Synonyms

17alpha-hydroxyprogesterone + O2 + reduced (NADPH--hemoprotein reductase) => 11-deoxycortisol + H(+) + H2O + oxidized (NADPH--hemoprotein reductase), Hydroxylation of 17-hydroxyprogesterone to form 11-deoxycortisol, 17-hydroxyprogesterone + NADPH + H+ + O2 => 11-deoxycortisol + NADP+ + H2O

ReviewStatus

5/5

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17-Hydroxyprogesterone, NADPH + H+, and O2 react to form 11-deoxycortisol, NADP+, and H2O. This reaction is catalyzed by CYP21A2 (steroid 21-hydroxylase) associated with the endoplasmic reticulum membrane.

Literature References

PubMed ID	Title	Journal	Year
3487786	Structure of human steroid 21-hydroxylase genes White, PC, New, MI, Dupont, B	Proc Natl Acad Sci U S A	1986
3038528	Molecular characterization of the HLA-linked steroid 21-hydroxylase B gene from an individual with congenital adrenal hyperplasia Rodrigues, NR, Dunham, I, Yu, CY, Carroll, MC, Porter, RR, Campbell, RD	EMBO J	1987