Reactome | CYP21A2 oxidises 17HPROG

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CYP21A2 oxidises 17HPROG Show undefined attributes

catalystActivity	[CatalystActivity:10746338] progesterone 21-hydroxylase activity of CYP21A2 [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10746342
displayName	CYP21A2 oxidises 17HPROG
eventOf	[Pathway:R-GGA-194002] Glucocorticoid biosynthesis - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-193981] CYP21A2 oxidises 17HPROG - Homo sapiens
input	[SimpleEntity:R-ALL-193092] 17aHPROG [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29364] NADPH [cytosol] [SimpleEntity:R-ALL-29368] O2 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	CYP21A2 oxidises 17HPROG 17alpha-hydroxyprogesterone + O2 + reduced (NADPH--hemoprotein reductase) => 11-deoxycortisol + H(+) + H2O + oxidized (NADPH--hemoprotein reductase) Hydroxylation of 17-hydroxyprogesterone to form 11-deoxycortisol 17-hydroxyprogesterone + NADPH + H+ + O2 => 11-deoxycortisol + NADP+ + H2O
output	[SimpleEntity:R-ALL-193966] 11-deoxycortisol [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-29366] NADP+ [cytosol]
precedingEvent	[Reaction:R-GGA-193072] CYP17A1 17-hydroxylates P4 to 17aHPROG - Gallus gallus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-193981
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-194002] Glucocorticoid biosynthesis
(inferredTo)	[Reaction:R-HSA-193981] CYP21A2 oxidises 17HPROG

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