Reactome | Regulated proteolysis of p75NTR

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Regulated proteolysis of p75NTR Show undefined attributes

authored	[InstanceEdit:188342] Nasi, Sergio, Annibali, D, 2006-10-10
created	[InstanceEdit:193693] Jassal, B, 2007-02-23 15:02:35
dbId	193692
displayName	Regulated proteolysis of p75NTR
edited	[InstanceEdit:350668] Jassal, B, 2008-05-20 12:26:36
eventOf	[Pathway:R-HSA-193704] p75 NTR receptor-mediated signalling - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:172499] membrane protein intracellular domain proteolysis
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-193679] alpha-secretase cleaves the p75NTR extracellular domain - Homo sapiens [Reaction:R-HSA-209532] The p75NTR C-terminal fragment enters endosomes - Homo sapiens [Reaction:R-HSA-193682] gamma-secretase cleaves the p75NTR transmembrane domain - Homo sapiens [Reaction:R-HSA-193700] p75NTR ICD signals to NF-kB - Homo sapiens [Reaction:R-HSA-193702] Part of the ICD migrates to the nucleus - Homo sapiens
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:210957] Metalloproteases and gamma-secretase: new membrane partners regulating p75 neurotrophin receptor signaling?
maxDepth	2
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	Regulated proteolysis of p75NTR
orthologousEvent	[Pathway:R-DRE-193692] Regulated proteolysis of p75NTR - Danio rerio [Pathway:R-GGA-193692] Regulated proteolysis of p75NTR - Gallus gallus [Pathway:R-XTR-193692] Regulated proteolysis of p75NTR - Xenopus tropicalis [Pathway:R-SSC-193692] Regulated proteolysis of p75NTR - Sus scrofa [Pathway:R-BTA-193692] Regulated proteolysis of p75NTR - Bos taurus [Pathway:R-CFA-193692] Regulated proteolysis of p75NTR - Canis familiaris [Pathway:R-RNO-193692] Regulated proteolysis of p75NTR - Rattus norvegicus [Pathway:R-MMU-193692] Regulated proteolysis of p75NTR - Mus musculus
releaseDate	2008-06-30
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:350667] Friedman, WJ, 2008-05-20 12:23:46 [InstanceEdit:351795] Chao, MV, 2008-05-28 09:46:01
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-193692
summation	[Summation:194492] p75NTR undergoes a process of regulated intramembrane proteo...

Referrals

(hasEvent)

[Pathway:R-HSA-193704] p75 NTR receptor-mediated signalling