Reactome | gamma-secretase cleaves the p75NTR transmembrane domain

Schema > Reaction > Entries

gamma-secretase cleaves the p75NTR transmembrane domain Show undefined attributes

authored	[InstanceEdit:188342] Nasi, Sergio, Annibali, D, 2006-10-10
catalystActivity	[CatalystActivity:194541] endopeptidase activity of gamma-secretase complex [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:17941] early endosome
created	[InstanceEdit:193693] Jassal, B, 2007-02-23 15:02:35
dbId	193682
displayName	gamma-secretase cleaves the p75NTR transmembrane domain
edited	[InstanceEdit:350668] Jassal, B, 2008-05-20 12:26:36
eventOf	[Pathway:R-HSA-193692] Regulated proteolysis of p75NTR - Homo sapiens
followingEvent	[Reaction:R-HSA-193700] p75NTR ICD signals to NF-kB - Homo sapiens [Reaction:R-HSA-193702] Part of the ICD migrates to the nucleus - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-194476] NGFR(251-427) [plasma membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:194570] Proteolytic processing of the p75 neurotrophin receptor and two homologs generates C-terminal fragments with signaling capability
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	gamma-secretase cleaves the p75NTR transmembrane domain
orthologousEvent	[Reaction:R-DRE-193682] gamma-secretase cleaves the p75NTR transmembrane domain - Danio rerio [Reaction:R-GGA-193682] gamma-secretase cleaves the p75NTR transmembrane domain - Gallus gallus [Reaction:R-XTR-193682] gamma-secretase cleaves the p75NTR transmembrane domain - Xenopus tropicalis [Reaction:R-SSC-193682] gamma-secretase cleaves the p75NTR transmembrane domain - Sus scrofa [Reaction:R-BTA-193682] gamma-secretase cleaves the p75NTR transmembrane domain - Bos taurus [Reaction:R-CFA-193682] gamma-secretase cleaves the p75NTR transmembrane domain - Canis familiaris [Reaction:R-RNO-193682] gamma-secretase cleaves the p75NTR transmembrane domain - Rattus norvegicus [Reaction:R-MMU-193682] gamma-secretase cleaves the p75NTR transmembrane domain - Mus musculus
output	[EntityWithAccessionedSequence:R-HSA-194509] NGFR(251-272) [plasma membrane] [EntityWithAccessionedSequence:R-HSA-194458] NGFR(273-427) [cytosol]
precedingEvent	[Reaction:R-HSA-209532] The p75NTR C-terminal fragment enters endosomes - Homo sapiens
releaseDate	2008-06-30
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:350667] Friedman, WJ, 2008-05-20 12:23:46 [InstanceEdit:351795] Chao, MV, 2008-05-28 09:46:01
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-193682
summation	[Summation:194575] Within early endosomes, p75NTR C-Terminal Fragment undergoes...

Referrals

(precedingEvent)	[Reaction:R-HSA-193700] p75NTR ICD signals to NF-kB [Reaction:R-HSA-193702] Part of the ICD migrates to the nucleus
(hasEvent)	[Pathway:R-HSA-193692] Regulated proteolysis of p75NTR