Reactome | Regulated proteolysis of p75NTR

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Regulated proteolysis of p75NTR Show undefined attributes

created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10223195
displayName	Regulated proteolysis of p75NTR
eventOf	[Pathway:R-RNO-193704] p75 NTR receptor-mediated signalling - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:172499] membrane protein intracellular domain proteolysis
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-RNO-193679] alpha-secretase cleaves the p75NTR extracellular domain - Rattus norvegicus [Reaction:R-RNO-209532] The p75NTR C-terminal fragment enters endosomes - Rattus norvegicus [Reaction:R-RNO-193682] gamma-secretase cleaves the p75NTR transmembrane domain - Rattus norvegicus [Reaction:R-RNO-193700] p75NTR ICD signals to NF-kB - Rattus norvegicus [Reaction:R-RNO-193702] Part of the ICD migrates to the nucleus - Rattus norvegicus
inferredFrom	[Pathway:R-HSA-193692] Regulated proteolysis of p75NTR - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Regulated proteolysis of p75NTR
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48895] Rattus norvegicus
stId	R-RNO-193692
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-193704] p75 NTR receptor-mediated signalling
(inferredTo)	[Pathway:R-HSA-193692] Regulated proteolysis of p75NTR

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