Within early endosomes, p75NTR C-Terminal Fragment undergoes...

created [InstanceEdit:194547] Jassal, B, 2007-03-22 14:22:32
dbId 194575
displayName Within early endosomes, p75NTR C-Terminal Fragment undergoes...
modified [InstanceEdit:209557] Jassal, B, 2007-12-19 10:40:30
schemaClass Summation
text Within early endosomes, p75NTR C-Terminal Fragment undergoes processing by gamma-secretase, a complex composed of a presenilin homodimer (PSEN1 or PSEN2), nicastrin (NCSTN), APH1 (APH1A or APH1B) and PEN2. Such a minimal complex is sufficient for secretase activity, although other components may exist. The p75NTR cleavage by gamma-secretase gives rise to a 20-kD ICD (IntraCellular Domain) fragment, and to a small peptide, the significance of which is unknown but that is analogous to the A-beta peptides generated from amyloid precursor protein. p75NTR ICD may have cytoplasmic and nuclear signalling functions and it is unstable.
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