Reactome | FDPS dimer transfers IPPP to GPP

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FDPS dimer transfers IPPP to GPP Show undefined attributes

authored	[InstanceEdit:191754] Jassal, B, 2007-01-24 15:15:12
catalystActivity	[CatalystActivity:981559] (2E,6E)-farnesyl diphosphate synthase activity of holo-FDPS dimer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:191331] Jassal, Bijay, 2007-01-19
crossReference	[DatabaseIdentifier:12668098] RHEA:19362 [DatabaseIdentifier:9945085] RHEA:19362
dbId	191303
displayName	FDPS dimer transfers IPPP to GPP
edited	[InstanceEdit:191754] Jassal, B, 2007-01-24 15:15:12
eventOf	[Pathway:R-HSA-9969896] Lanosterol biosynthesis - Homo sapiens
followingEvent	[Reaction:R-HSA-191405] Two FAPP molecules dimerize to form presqualene diphosphate - Homo sapiens
input	[SimpleEntity:R-ALL-191409] GPP [cytosol] [SimpleEntity:R-ALL-191362] IPPP [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:191398] Human geranylgeranyl diphosphate synthase. cDNA cloning and expression. [LiteratureReference:191275] Human geranylgeranyl diphosphate synthase: isolation of the cDNA, chromosomal mapping and tissue expression [LiteratureReference:981558] The molecular mechanism of nitrogen-containing bisphosphonates as antiosteoporosis drugs
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	FDPS dimer transfers IPPP to GPP isopentenyl diphosphate + (2E)-geranyl diphosphate => (2E,6E)-farnesyl diphosphate + diphosphate Another isopentenyl pyrophosphate is added to geranyl pyrophosphate
orthologousEvent	[Reaction:R-PFA-191303] FDPS dimer transfers IPPP to GPP - Plasmodium falciparum [Reaction:R-SCE-191303] FDPS dimer transfers IPPP to GPP - Saccharomyces cerevisiae [Reaction:R-SPO-191303] FDPS dimer transfers IPPP to GPP - Schizosaccharomyces pombe [Reaction:R-DDI-191303] FDPS dimer transfers IPPP to GPP - Dictyostelium discoideum [Reaction:R-CEL-191303] FDPS dimer transfers IPPP to GPP - Caenorhabditis elegans [Reaction:R-DME-191303] FDPS dimer transfers IPPP to GPP - Drosophila melanogaster [Reaction:R-GGA-191303] FDPS dimer transfers IPPP to GPP - Gallus gallus [Reaction:R-DRE-191303] FDPS dimer transfers IPPP to GPP - Danio rerio [Reaction:R-SSC-191303] FDPS dimer transfers IPPP to GPP - Sus scrofa [Reaction:R-CFA-191303] FDPS dimer transfers IPPP to GPP - Canis familiaris [Reaction:R-RNO-191303] FDPS dimer transfers IPPP to GPP - Rattus norvegicus [Reaction:R-MMU-191303] FDPS dimer transfers IPPP to GPP - Mus musculus
output	[SimpleEntity:R-ALL-191385] FAPP [cytosol] [SimpleEntity:R-ALL-111294] PPi [cytosol]
precedingEvent	[Reaction:R-HSA-191322] FDPS dimer transfers IPPP to DMAPP - Homo sapiens [Reaction:R-HSA-9717834] GGPS1 hexamer transfers IPPP to DMAPP - Homo sapiens [Reaction:R-HSA-191414] MVD decarboxylates MVA5PP to IPPP - Homo sapiens
releaseDate	2007-02-20
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:191591] D'Eustachio, P, 2007-01-22 01:32:07
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-191303
summation	[Summation:191267] Further condensation of an isopentenyl pyrophosphate (IPPP) ...
updateTrackers	[UpdateTracker:9971933] Update Tracker - [Reaction:191303] FDPS dimer transfers IPPP to GPP - v95:[modifyText] [UpdateTracker:9790174] Update Tracker - [Reaction:191303] FDPS dimer transfers IPPP to GPP - v35:[addLiteratureReference, add_removeCatalystActivity, modifyText] [UpdateTracker:9776251] Update Tracker - [Reaction:191303] FDPS dimer transfers IPPP to GPP - v77:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9971933] Update Tracker - [Reaction:191303] FDPS dimer transfers IPPP to GPP - v95:[modifyText] [UpdateTracker:9790174] Update Tracker - [Reaction:191303] FDPS dimer transfers IPPP to GPP - v35:[addLiteratureReference, add_removeCatalystActivity, modifyText] [UpdateTracker:9776251] Update Tracker - [Reaction:191303] FDPS dimer transfers IPPP to GPP - v77:[modifyText]
(hasEvent)	[Pathway:R-HSA-9969896] Lanosterol biosynthesis
(precedingEvent)	[Reaction:R-HSA-191405] Two FAPP molecules dimerize to form presqualene diphosphate