NOTCH4 mRNA translation controlled by miRNAs

Stable Identifier
R-HSA-1912410
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
cytosol, endoplasmic reticulum membrane
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NOTCH4 mRNA translation controlled by miRNAs
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Translation of NOTCH4 mRNA is negatively regulated by miR-181c (Hashimoto et al. 2010) and miR-302A microRNAs (Costa et al. 2009). These miRNAs bind and cause degradation of NOTCH4 mRNA, resulting in decreased level of NOTCH4 protein product.

Literature References
PubMed ID Title Journal Year
20495621 Epigenetically reprogramming metastatic tumor cells with an embryonic microenvironment

Arndt, K, Costa, FF, Bischof, JM, Seftor, EA, Soares, MB, Hendrix, MJC, Kirschmann, DA, de Fatima Bonaldo, M, Strizzi, L

Epigenomics 2009
20080834 Involvement of epigenetically silenced microRNA-181c in gastric carcinogenesis

Yuasa, Y, Akiyama, Y, Shimada, S, Hashimoto, Y, Otsubo, T

Carcinogenesis 2010
Participants
Input
Output
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as an event of
Event Information
Go Biological Process
miRNA-mediated gene silencing by inhibition of translation (0035278)
This event is regulated
Negatively by
Regulator
NOTCH4 mRNA:miR-181C RISC [cytosol] (Homo sapiens)
Active Unit
miR-181C RISC [cytosol]
Regulator
NOTCH4 mRNA:miR-302A RISC [cytosol] (Homo sapiens)
Active Unit
miR-302A RISC [cytosol]
Authored
Orlic-Milacic, M  (2011-11-14)
Egan, SE  (2011-11-14)
Reviewed
Haw, R  (2012-02-06)
Created
Orlic-Milacic, M  (2011-11-01)
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