NOTCH4 mRNA translation controlled by miRNAs

Stable Identifier
R-HSA-1912410
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol, endoplasmic reticulum membrane
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NOTCH4 mRNA translation controlled by miRNAs
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Translation of NOTCH4 mRNA is negatively regulated by miR-181c (Hashimoto et al. 2010) and miR-302A microRNAs (Costa et al. 2009). These miRNAs bind and cause degradation of NOTCH4 mRNA, resulting in decreased level of NOTCH4 protein product.

Literature References
PubMed ID Title Journal Year
20080834 Involvement of epigenetically silenced microRNA-181c in gastric carcinogenesis

Hashimoto, Y, Akiyama, Y, Otsubo, T, Shimada, S, Yuasa, Y

Carcinogenesis 2010
20495621 Epigenetically reprogramming metastatic tumor cells with an embryonic microenvironment

Costa, FF, Seftor, EA, Bischof, JM, Kirschmann, DA, Strizzi, L, Arndt, K, de Fatima Bonaldo, M, Soares, MB, Hendrix, MJC

Epigenomics 2009
Participants
Input
Output
Participant Of
hasEvent
Event Information
Go Biological Process
miRNA mediated inhibition of translation (0035278)
This event is regulated
Negatively by
Authored
Egan, SE  (2011-11-14)
Orlic-Milacic, M  (2011-11-14)
Reviewed
Haw, R  (2012-02-06)
Created
Orlic-Milacic, M  (2011-11-02)