Reactome | Autocatalytic phosphorylation of FGFR1b

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Autocatalytic phosphorylation of FGFR1b Show undefined attributes

authored	[InstanceEdit:190908] de Bono, B, 2007-01-10 10:27:18
catalystActivity	[CatalystActivity:190428] protein tyrosine kinase activity of FGFR1b homodimer bound to FGF [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:190433] de Bono, B, 2007-01-02 16:43:07
dbId	190427
displayName	Autocatalytic phosphorylation of FGFR1b
eventOf	[Pathway:R-HSA-190370] FGFR1b ligand binding and activation - Homo sapiens
followingEvent	[Reaction:R-HSA-5656064] Activated FGFR1 binds FLRT1,2,3 - Homo sapiens [Reaction:R-HSA-5654571] Activated FGFR1 binds FRS3 - Homo sapiens [Reaction:R-HSA-5654573] Activated FGFR1 binds SHC1 - Homo sapiens [Reaction:R-HSA-5654167] Activated FGFR1 binds PLCG1 - Homo sapiens [Reaction:R-HSA-5654569] Activated FGFR1 binds FRS2 - Homo sapiens
input	16 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-190226] FGFR1b homodimer bound to FGF [plasma membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:190942] Identification of six novel autophosphorylation sites on fibroblast growth factor receptor 1 and elucidation of their importance in receptor activation and signal transduction [LiteratureReference:1295588] Point mutation in FGF receptor eliminates phosphatidylinositol hydrolysis without affecting mitogenesis [LiteratureReference:191025] A tyrosine-phosphorylated carboxy-terminal peptide of the fibroblast growth factor receptor (Flg) is a binding site for the SH2 domain of phospholipase C-gamma 1 [LiteratureReference:443277] Autophosphorylation of FGFR1 kinase is mediated by a sequential and precisely ordered reaction
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	Autocatalytic phosphorylation of FGFR1b
orthologousEvent	[Reaction:R-CEL-190427] Autocatalytic phosphorylation of FGFR1b - Caenorhabditis elegans [Reaction:R-DME-190427] Autocatalytic phosphorylation of FGFR1b - Drosophila melanogaster [Reaction:R-GGA-190427] Autocatalytic phosphorylation of FGFR1b - Gallus gallus [Reaction:R-XTR-190427] Autocatalytic phosphorylation of FGFR1b - Xenopus tropicalis [Reaction:R-DRE-190427] Autocatalytic phosphorylation of FGFR1b - Danio rerio [Reaction:R-SSC-190427] Autocatalytic phosphorylation of FGFR1b - Sus scrofa [Reaction:R-BTA-190427] Autocatalytic phosphorylation of FGFR1b - Bos taurus [Reaction:R-CFA-190427] Autocatalytic phosphorylation of FGFR1b - Canis familiaris [Reaction:R-RNO-190427] Autocatalytic phosphorylation of FGFR1b - Rattus norvegicus [Reaction:R-MMU-190427] Autocatalytic phosphorylation of FGFR1b - Mus musculus
output	[Complex:R-HSA-190430] Activated FGFR1b homodimer [plasma membrane] 16 × [SimpleEntity:R-ALL-29370] ADP [cytosol]
precedingEvent	[Reaction:R-HSA-190245] FGFR1b binds to FGF - Homo sapiens
releaseDate	2007-02-28
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:192607] Mohammadi, M, 2007-02-06 21:44:35
revised	[InstanceEdit:1493881] Rothfels, K, 2011-08-16
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-190427
summation	[Summation:191577] Studies have mapped 8 tyrosine residues in the cytoplasmic d...
updateTrackers	[UpdateTracker:9789890] Update Tracker - [Reaction:190427] Autocatalytic phosphorylation of FGFR1b - v37:[addLiteratureReference, modifyText] [UpdateTracker:9792365] Update Tracker - [Reaction:190427] Autocatalytic phosphorylation of FGFR1b - v22:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9789890] Update Tracker - [Reaction:190427] Autocatalytic phosphorylation of FGFR1b - v37:[addLiteratureReference, modifyText] [UpdateTracker:9792365] Update Tracker - [Reaction:190427] Autocatalytic phosphorylation of FGFR1b - v22:[modifyText]
(hasEvent)	[Pathway:R-HSA-190370] FGFR1b ligand binding and activation
(precedingEvent)	[Reaction:R-HSA-5656064] Activated FGFR1 binds FLRT1,2,3 [Reaction:R-HSA-5654571] Activated FGFR1 binds FRS3 [Reaction:R-HSA-5654573] Activated FGFR1 binds SHC1 [Reaction:R-HSA-5654167] Activated FGFR1 binds PLCG1 [Reaction:R-HSA-5654569] Activated FGFR1 binds FRS2

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