Reactome | Autocatalytic phosphorylation of FGFR1b

Schema > Reaction > Entries

Autocatalytic phosphorylation of FGFR1b Show undefined attributes

catalystActivity	[CatalystActivity:10348550] protein tyrosine kinase activity of FGFR1b homodimer bound to FGF [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10348552
displayName	Autocatalytic phosphorylation of FGFR1b
eventOf	[Pathway:R-BTA-190370] FGFR1b ligand binding and activation - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-BTA-5656064] Activated FGFR1 binds FLRT1,2,3 - Bos taurus [Reaction:R-BTA-5654571] Activated FGFR1 binds FRS3 - Bos taurus [Reaction:R-BTA-5654573] Activated FGFR1 binds SHC1 - Bos taurus [Reaction:R-BTA-5654167] Activated FGFR1 binds PLCG1 - Bos taurus [Reaction:R-BTA-5654569] Activated FGFR1 binds FRS2 - Bos taurus
inferredFrom	[Reaction:R-HSA-190427] Autocatalytic phosphorylation of FGFR1b - Homo sapiens
input	16 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-BTA-190226] FGFR1b homodimer bound to FGF [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	Autocatalytic phosphorylation of FGFR1b
output	[Complex:R-BTA-190430] Activated FGFR1b homodimer [plasma membrane] 16 × [SimpleEntity:R-ALL-29370] ADP [cytosol]
precedingEvent	[Reaction:R-BTA-190245] FGFR1b binds to FGF - Bos taurus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-190427
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-190370] FGFR1b ligand binding and activation
(precedingEvent)	[Reaction:R-BTA-5656064] Activated FGFR1 binds FLRT1,2,3 [Reaction:R-BTA-5654571] Activated FGFR1 binds FRS3 [Reaction:R-BTA-5654573] Activated FGFR1 binds SHC1 [Reaction:R-BTA-5654167] Activated FGFR1 binds PLCG1 [Reaction:R-BTA-5654569] Activated FGFR1 binds FRS2
(inferredTo)	[Reaction:R-HSA-190427] Autocatalytic phosphorylation of FGFR1b