Reactome | FGFR1c and Klotho ligand binding and activation

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FGFR1c and Klotho ligand binding and activation Show undefined attributes

authored	[InstanceEdit:190908] de Bono, B, 2007-01-10 10:27:18
created	[InstanceEdit:190369] de Bono, B, 2007-01-02 13:52:03
dbId	190374
deleted	[Deleted:6789867] Deletion of instance: 1307973
displayName	FGFR1c and Klotho ligand binding and activation
eventOf	[Pathway:R-HSA-190242] FGFR1 ligand binding and activation - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:24611] fibroblast growth factor receptor signaling pathway
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-190268] FGFR1c binds to Klotho-bound FGF23 - Homo sapiens [Reaction:R-HSA-191062] Autocatalytic phosphorylation of Klotho-bound FGFR1c - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2023-09-13
literatureReference	[LiteratureReference:190266] Klotho converts canonical FGF receptor into a specific receptor for FGF23 [LiteratureReference:1307942] Regulation of fibroblast growth factor-23 signaling by klotho
maxDepth	2
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	FGFR1c and Klotho ligand binding and activation
orthologousEvent	[Pathway:R-SSC-190374] FGFR1c and Klotho ligand binding and activation - Sus scrofa [Pathway:R-DME-190374] FGFR1c and Klotho ligand binding and activation - Drosophila melanogaster [Pathway:R-GGA-190374] FGFR1c and Klotho ligand binding and activation - Gallus gallus [Pathway:R-XTR-190374] FGFR1c and Klotho ligand binding and activation - Xenopus tropicalis [Pathway:R-DRE-190374] FGFR1c and Klotho ligand binding and activation - Danio rerio [Pathway:R-BTA-190374] FGFR1c and Klotho ligand binding and activation - Bos taurus [Pathway:R-CFA-190374] FGFR1c and Klotho ligand binding and activation - Canis familiaris [Pathway:R-RNO-190374] FGFR1c and Klotho ligand binding and activation - Rattus norvegicus [Pathway:R-MMU-190374] FGFR1c and Klotho ligand binding and activation - Mus musculus
releaseDate	2007-02-28
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:192607] Mohammadi, M, 2007-02-06 21:44:35
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-190374
summation	[Summation:190971] FGF23 is a member of the endocrine subfamily of FGFs. It is ...
updateTrackers	[UpdateTracker:9788966] Update Tracker - [Pathway:190374] FGFR1c and Klotho ligand binding and activation - v39:[updateContainedRLE] [UpdateTracker:9792383] Update Tracker - [Pathway:190374] FGFR1c and Klotho ligand binding and activation - v22:[updateContainedRLE] [UpdateTracker:9789771] Update Tracker - [Pathway:190374] FGFR1c and Klotho ligand binding and activation - v37:[addLiteratureReference, modifyText, updateContainedRLE] [UpdateTracker:9842327] Update Tracker - [Pathway:190374] FGFR1c and Klotho ligand binding and activation - v86:[updateContainedRLE] [UpdateTracker:9790979] Update Tracker - [Pathway:190374] FGFR1c and Klotho ligand binding and activation - v32:[updateContainedRLE]

Referrals

(updatedInstance)	[UpdateTracker:9788966] Update Tracker - [Pathway:190374] FGFR1c and Klotho ligand binding and activation - v39:[updateContainedRLE] [UpdateTracker:9792383] Update Tracker - [Pathway:190374] FGFR1c and Klotho ligand binding and activation - v22:[updateContainedRLE] [UpdateTracker:9789771] Update Tracker - [Pathway:190374] FGFR1c and Klotho ligand binding and activation - v37:[addLiteratureReference, modifyText, updateContainedRLE] [UpdateTracker:9842327] Update Tracker - [Pathway:190374] FGFR1c and Klotho ligand binding and activation - v86:[updateContainedRLE] [UpdateTracker:9790979] Update Tracker - [Pathway:190374] FGFR1c and Klotho ligand binding and activation - v32:[updateContainedRLE]
(replacementInstances)	[Deleted:6789867] Deletion of instance: 1307973
(hasEvent)	[Pathway:R-HSA-190242] FGFR1 ligand binding and activation

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