FGFR1c and Klotho ligand binding and activation

Stable Identifier
R-HSA-190374
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Pathway
Species
Homo sapiens
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FGF23 is a member of the endocrine subfamily of FGFs. It is produced in bone tissue and regulates kidney functions. Klotho is essential for endogenous FGF23 function as it converts FGFR1c into a specific FGF23 receptor.

Literature References
PubMed ID Title Journal Year
16436388 Regulation of fibroblast growth factor-23 signaling by klotho

Kurosu, H, Ogawa, Y, Miyoshi, M, Yamamoto, M, Nandi, A, Rosenblatt, KP, Baum, MG, Schiavi, S, Hu, MC, Moe, OW, Kuro-O, M

J Biol Chem 2006
17086194 Klotho converts canonical FGF receptor into a specific receptor for FGF23

Fujita, T, Fukumoto, S, Hasegawa, H, Iijima, K, Okawa, K, Shimada, T, Urakawa, I, Yamazaki, Y, Yameshita, T

Nature 2006
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