FGFR1c and Klotho ligand binding and activation

Stable Identifier
R-HSA-190374
Type
Pathway
Species
Homo sapiens
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FGF23 is a member of the endocrine subfamily of FGFs. It is produced in bone tissue and regulates kidney functions. Klotho is essential for endogenous FGF23 function as it converts FGFR1c into a specific FGF23 receptor.

Literature References
PubMed ID Title Journal Year
17086194 Klotho converts canonical FGF receptor into a specific receptor for FGF23

Yamazaki, Y, Fukumoto, S, Shimada, T, Iijima, K, Urakawa, I, Okawa, K, Fujita, T, Yameshita, T, Hasegawa, H

Nature 2006
16436388 Regulation of fibroblast growth factor-23 signaling by klotho

Kuro-O, M, Baum, MG, Miyoshi, M, Ogawa, Y, Schiavi, S, Nandi, A, Kurosu, H, Rosenblatt, KP, Yamamoto, M, Hu, MC, Moe, OW

J Biol Chem 2006
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Orthologous Events
Cross References
GlyCosmos
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