Reactome | FGFR1b homodimer [plasma membrane]

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FGFR1b homodimer [plasma membrane] Show undefined attributes

catalystActivities	[CatalystActivity:1982067] protein tyrosine kinase activity of FGFR1b homodimer [plasma membrane]
compartment	[Compartment:876] plasma membrane
componentOf	[Complex:R-HSA-190226] FGFR1b homodimer bound to FGF [plasma membrane] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-1982066] Ligand-independent phosphorylation of overexpressed FGFR1 - Homo sapiens
created	[InstanceEdit:190229] de Bono, B, 2006-12-18 13:54:50
crossReference	[DatabaseIdentifier:12020750] Mondo:0005212
dbId	190228
disease	[Disease:1493885] bladder carcinoma [Disease:1500576] breast cancer [Disease:1248679] head and neck squamous cell carcinoma [Disease:1981182] lung squamous cell carcinoma [Disease:1500575] ovarian cancer [Disease:1614291] rhabdomyosarcoma
displayName	FGFR1b homodimer [plasma membrane]
hasComponent	2 × [EntityWithAccessionedSequence:R-HSA-189878] FGFR1b [plasma membrane]
inDisease	true
inferredTo	[Complex:R-MMU-190228] FGFR1b homodimer [plasma membrane] - Mus musculus [Complex:R-RNO-190228] FGFR1b homodimer [plasma membrane] - Rattus norvegicus [Complex:R-CFA-190228] FGFR1b homodimer [plasma membrane] - Canis familiaris [Complex:R-BTA-190228] FGFR1b homodimer [plasma membrane] - Bos taurus [Complex:R-SSC-190228] FGFR1b homodimer [plasma membrane] - Sus scrofa [Complex:R-DRE-190228] FGFR1b homodimer [plasma membrane] - Danio rerio [Complex:R-XTR-190228] FGFR1b homodimer [plasma membrane] - Xenopus tropicalis [Complex:R-GGA-190228] FGFR1b homodimer [plasma membrane] - Gallus gallus [Complex:R-DME-190228] FGFR1b homodimer [plasma membrane] - Drosophila melanogaster [Complex:R-CEL-190228] FGFR1b homodimer [plasma membrane] - Caenorhabditis elegans
maxDepth	2
memberOf	[DefinedSet:R-HSA-1982053] Overexpressed FGFR1 homodimers [plasma membrane] - Homo sapiens
modified	[InstanceEdit:5655225] Rothfels, Karen, 2014-12-05
name	FGFR1b homodimer
producedByEvent	[Reaction:R-HSA-1982065] Ligand-independent dimerization of overexpressed FGFR1b - Homo sapiens
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-190228
updateTrackers	[UpdateTracker:9891619] Update Tracker - [Complex:190228] FGFR1b homodimer [plasma membrane] - v52:[addDisease]

Referrals

(updatedInstance)	[UpdateTracker:9891619] Update Tracker - [Complex:190228] FGFR1b homodimer [plasma membrane] - v52:[addDisease]
(input)	[Reaction:R-HSA-1982066] Ligand-independent phosphorylation of overexpressed FGFR1
(diseaseEntity)	[EntityFunctionalStatus:5654531] gain_of_function of FGFR1b homodimer [plasma membrane]
(physicalEntity)	[CatalystActivity:1982067] protein tyrosine kinase activity of FGFR1b homodimer [plasma membrane]
(output)	[Reaction:R-HSA-1982065] Ligand-independent dimerization of overexpressed FGFR1b
(hasMember)	[DefinedSet:R-HSA-1982053] Overexpressed FGFR1 homodimers [plasma membrane]
(hasComponent)	[Complex:R-HSA-190226] FGFR1b homodimer bound to FGF [plasma membrane]

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