Reactome | CPO transforms COPRO3 to PPGEN9

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CPO transforms COPRO3 to PPGEN9 Show undefined attributes

catalystActivity	[CatalystActivity:11085494] coproporphyrinogen oxidase activity of 2xCPO [mitochondrial intermembrane space]
category	transition
compartment	[Compartment:17927] mitochondrial intermembrane space
created	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
dbId	11085496
displayName	CPO transforms COPRO3 to PPGEN9
eventOf	[Pathway:R-SCE-189451] Heme biosynthesis - Saccharomyces cerevisiae
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-SCE-189423] PPO oxidises PPGEN9 to PRIN9 - Saccharomyces cerevisiae
inferredFrom	[Reaction:R-HSA-189421] CPO transforms COPRO3 to PPGEN9 - Homo sapiens
input	[SimpleEntity:R-ALL-189411] COPRO3 [mitochondrial intermembrane space] [SimpleEntity:R-ALL-163953] H+ [mitochondrial intermembrane space] [SimpleEntity:R-ALL-189461] O2 [mitochondrial intermembrane space]
isInDisease	false
isInferred	true
maxDepth	1
name	CPO transforms COPRO3 to PPGEN9 coproporphyrinogen III + 2 H(+) + O2 => 2 CO2 + 2 H2O + protoporphyrinogen IX Conversion of coproporphyrinogen III to protoporphyrinogen IX
output	2 × [SimpleEntity:R-ALL-189480] CO2 [mitochondrial intermembrane space] [SimpleEntity:R-ALL-189422] H2O [mitochondrial intermembrane space] [SimpleEntity:R-ALL-189478] PPGEN9 [mitochondrial intermembrane space]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68322] Saccharomyces cerevisiae
stId	R-SCE-189421
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SCE-189451] Heme biosynthesis
(precedingEvent)	[Reaction:R-SCE-189423] PPO oxidises PPGEN9 to PRIN9
(inferredTo)	[Reaction:R-HSA-189421] CPO transforms COPRO3 to PPGEN9

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