Reactome | Monoubiquitination of N-myristoyl GAG polyprotein

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Monoubiquitination of N-myristoyl GAG polyprotein Show undefined attributes

authored	[InstanceEdit:3211410] Gillespie, ME, 2013-03-06
category	omitted
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:184440] D'Eustachio, P, 2006-07-27 16:05:42
crossReference	[DatabaseIdentifier:12020765] Mondo:0005109
dbId	184323
disease	[Disease:1660559] Human immunodeficiency virus infectious disease
displayName	Monoubiquitination of N-myristoyl GAG polyprotein
eventOf	[Pathway:R-HSA-174490] Membrane binding and targetting of GAG proteins - Homo sapiens
followingEvent	[Reaction:R-HSA-184269] Monoubiquitinated N-myristoyl GAG polyprotein is targeted to the late endosomal vesicle membrane by the ESCRT-I complex - Homo sapiens
input	[EntityWithAccessionedSequence:R-HIV-184427] N-myristoyl GAG (P04591) protein [cytosol] [DefinedSet:R-HSA-113595] Ub [cytosol]
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:184308] Cumulative mutations of ubiquitin acceptor sites in human immunodeficiency virus type 1 gag cause a late budding defect [LiteratureReference:184430] Ubiquitin is covalently attached to the p6Gag proteins of human immunodeficiency virus type 1 and simian immunodeficiency virus and to the p12Gag protein of Moloney murine leukemia virus [LiteratureReference:184259] Ubiquitination of HIV-1 and MuLV Gag
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Monoubiquitination of N-myristoyl GAG polyprotein
output	[Complex:R-HSA-184369] monoubiquitinated N-myristoyl GAG (P04591) protein [cytosol]
precedingEvent	[Reaction:R-HSA-184392] N-myristoylation of GAG polyprotein by NMT2 - Homo sapiens
relatedSpecies	[Species:164493] Human immunodeficiency virus 1
releaseDate	2011-12-06
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:3595152] Dub�, Mathieu, 2013-05-21
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-184323
summation	[Summation:184425] Cytosolic N-myristoyl Gag polyprotein is conjugated with a s...
updateTrackers	[UpdateTracker:9787727] Update Tracker - [BlackBoxEvent:184323] Monoubiquitination of N-myristoyl GAG polyprotein - v44:[add_removeInput, add_removeOutput]

Referrals

(updatedInstance)	[UpdateTracker:9787727] Update Tracker - [BlackBoxEvent:184323] Monoubiquitination of N-myristoyl GAG polyprotein - v44:[add_removeInput, add_removeOutput]
(precedingEvent)	[Reaction:R-HSA-184269] Monoubiquitinated N-myristoyl GAG polyprotein is targeted to the late endosomal vesicle membrane by the ESCRT-I complex
(hasEvent)	[Pathway:R-HSA-174490] Membrane binding and targetting of GAG proteins

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