Reactome | Monoubiquitinated N-myristoyl GAG polyprotein is targeted to the late endosomal vesicle membrane by the ESCRT-I complex

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Monoubiquitinated N-myristoyl GAG polyprotein is targeted to the late endosomal vesicle membrane by the ESCRT-I complex Show undefined attributes

authored	[InstanceEdit:3211410] Gillespie, ME, 2013-03-06
catalystActivity	[CatalystActivity:3159230] protein transmembrane transporter activity of ESCRT-I [endosome membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:74700] endosome membrane
created	[InstanceEdit:184440] D'Eustachio, P, 2006-07-27 16:05:42
crossReference	[DatabaseIdentifier:12020765] Mondo:0005109
dbId	184269
disease	[Disease:1660559] Human immunodeficiency virus infectious disease
displayName	Monoubiquitinated N-myristoyl GAG polyprotein is targeted to the late endosomal vesicle membrane by the ESCRT-I complex
eventOf	[Pathway:R-HSA-174490] Membrane binding and targetting of GAG proteins - Homo sapiens
followingEvent	[Reaction:R-HSA-3149434] Transport of GAG to the Plasma Membrane - Homo sapiens
input	[Complex:R-HSA-184369] monoubiquitinated N-myristoyl GAG (P04591) protein [cytosol]
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:184315] Role of ESCRT-I in retroviral budding [LiteratureReference:184415] The human endosomal sorting complex required for transport (ESCRT-I) and its role in HIV-1 budding [LiteratureReference:184416] Identification of human VPS37C, a component of endosomal sorting complex required for transport-I important for viral budding
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Monoubiquitinated N-myristoyl GAG polyprotein is targeted to the late endosomal vesicle membrane by the ESCRT-I complex
output	[Complex:R-HSA-184475] monoubiquitinated N-myristoyl GAG (P04591) protein [endosome membrane]
precedingEvent	[BlackBoxEvent:R-HSA-184323] Monoubiquitination of N-myristoyl GAG polyprotein - Homo sapiens
relatedSpecies	[Species:164493] Human immunodeficiency virus 1
releaseDate	2011-12-06
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:3595152] Dub�, Mathieu, 2013-05-21
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-184269
summation	[Summation:184467] Monoubiquitinated N-myristoyl Gag polyprotein associates wit...
updateTrackers	[UpdateTracker:9787825] Update Tracker - [Reaction:184269] Monoubiquitinated N-myristoyl GAG polyprotein is targeted to the late endosomal vesicle membrane by the ESCRT-I complex - v44:[addCatalystActivity, add_removeInput, add_removeOutput]

Referrals

(updatedInstance)	[UpdateTracker:9787825] Update Tracker - [Reaction:184269] Monoubiquitinated N-myristoyl GAG polyprotein is targeted to the late endosomal vesicle membrane by the ESCRT-I complex - v44:[addCatalystActivity, add_removeInput, add_removeOutput]
(hasEvent)	[Pathway:R-HSA-174490] Membrane binding and targetting of GAG proteins
(precedingEvent)	[Reaction:R-HSA-3149434] Transport of GAG to the Plasma Membrane

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