C3(H2O):Factor Bb cleaves C3 to C3b and C3a

Stable Identifier
R-HSA-183130
Type
Reaction [transition]
Species
Homo sapiens
Compartment
extracellular region
ReviewStatus
5/5
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C3(H2O):Factor Bb cleaves C3 to C3b and C3a
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C3(H2O):Factor Bb is a C3 convertase, sometimes referred to as the initial C3 convertase (iC3). The Factor Bb component catalyzes the hydrolysis of C3 to produce C3b and C3a. This reaction is not known to be directly coupled to the association of C3b complexes with a cell surface. It is believed that a small proportion of C3b spontaneously associates with the cell surface, otherwise it is rapidly inactivated (Muller-Eberhard 1988).
Literature References
PubMed ID Title Journal Year
3052276 Molecular organization and function of the complement system

Muller-Eberhard, HJ

Annu Rev Biochem 1988
Participants
Input
Output
Participates
as an event of
Catalyst Activity

serine-type endopeptidase activity of C3(H2O):Bb [extracellular region]

Physical Entity
C3(H2O):Bb [extracellular region] (Homo sapiens)
Activity
serine-type endopeptidase activity (GO:0004252)
Orthologous Events
C3(H2O):Factor Bb cleaves C3 to C3b and C3a (Bos taurus)
C3(H2O):Factor Bb cleaves C3 to C3b and C3a (Canis familiaris)
C3(H2O):Factor Bb cleaves C3 to C3b and C3a (Danio rerio)
C3(H2O):Factor Bb cleaves C3 to C3b and C3a (Gallus gallus)
C3(H2O):Factor Bb cleaves C3 to C3b and C3a (Mus musculus)
C3(H2O):Factor Bb cleaves C3 to C3b and C3a (Sus scrofa)
C3(H2O):Factor Bb cleaves C3 to C3b and C3a (Xenopus tropicalis)
Authored
de Bono, B  (2006-02-16)
Reviewed
D'Eustachio, P  (2006-07-04)
Created
de Bono, B  (2006-07-21)
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