Reactome | EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane]

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EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane] Show undefined attributes

catalystActivities	[CatalystActivity:10840962] ubiquitin-protein transferase activity of EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane]
compartment	[Compartment:876] plasma membrane
componentOf	[Complex:R-DME-182931] EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:SPRY1/2:Endophilin:Epsin:Eps15L1:EPS15 [plasma membrane] - Drosophila melanogaster
consumedByEvent	[Reaction:R-DME-182990] Sprouty sequesters CBL away from active EGFR - Drosophila melanogaster [Reaction:R-DME-182986] CBL-mediated ubiquitination of CIN85 - Drosophila melanogaster
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10840950
displayName	EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane]
hasComponent	[Complex:R-DME-8875480] CIN85:endophilin [cytosol] [Complex:R-DME-182953] EGF-like ligands:p-6Y-EGFR:p-Y371-CBL [plasma membrane] [EntityWithAccessionedSequence:R-DME-182937] Eps-15 [plasma membrane] [Complex:R-DME-182947] EPS15:HGS:STAM [cytosol] [EntityWithAccessionedSequence:R-DME-182952] lqf [plasma membrane]
inDisease	false
inferredFrom	[Complex:R-HSA-182961] EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane] - Homo sapiens
maxDepth	5
name	EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15
producedByEvent	[Reaction:R-DME-183072] EGFR non-clathrin mediated endocytosis - Drosophila melanogaster
schemaClass	Complex
species	[Species:56210] Drosophila melanogaster
stId	R-DME-182961
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

Referrals

(input)	[Reaction:R-DME-182990] Sprouty sequesters CBL away from active EGFR [Reaction:R-DME-182986] CBL-mediated ubiquitination of CIN85
(hasComponent)	[Complex:R-DME-182931] EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:SPRY1/2:Endophilin:Epsin:Eps15L1:EPS15 [plasma membrane]
(physicalEntity)	[CatalystActivity:10840962] ubiquitin-protein transferase activity of EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane]
(output)	[Reaction:R-DME-183072] EGFR non-clathrin mediated endocytosis
(inferredTo)	[Complex:R-HSA-182961] EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane]

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