Reactome | Removal of plus-strand flap and gap closure complete synthesis of linear duplex viral DNA

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Removal of plus-strand flap and gap closure complete synthesis of linear duplex viral DNA Show undefined attributes

authored	[InstanceEdit:180401] Gopinathrao, G, D'Eustachio, P, 2006-05-18 20:10:22
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:182820] Gopinathrao, G, 2006-07-19 16:21:19
crossReference	[DatabaseIdentifier:12020765] Mondo:0005109
dbId	182876
disease	[Disease:1660559] Human immunodeficiency virus infectious disease
displayName	Removal of plus-strand flap and gap closure complete synthesis of linear duplex viral DNA
eventOf	[Pathway:R-HSA-162594] Early Phase of HIV Life Cycle - Homo sapiens
followingEvent	[Reaction:R-HSA-8951690] Formation of RTC with integration competent viral DNA:BANF1:HMGA1:PSIP1 - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:17126] RNA-templated DNA biosynthetic process
input	[Complex:R-HSA-188560] RTC with duplex DNA containing discontinuous plus strand flap [cytosol]
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:182836] 'Binding, bending and bonding': polypurine tract-primed initiation of plus-strand DNA synthesis in human immunodeficiency virus [LiteratureReference:182816] Human immunodeficiency virus type 1 preintegration complexes containing discontinuous plus strands are competent to integrate in vitro [LiteratureReference:182817] Processing of an HIV replication intermediate by the human DNA replication enzyme FEN1
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Removal of plus-strand flap and gap closure complete synthesis of linear duplex viral DNA
output	[Complex:R-HSA-175254] RTC with integration competent viral DNA [cytosol]
precedingEvent	[Reaction:R-HSA-164505] Synthesis of full-length duplex viral DNA with a discontinuous plus strand - Homo sapiens
regulatedBy	[Requirement:R-HSA-182796] Requirement by 'LIG1 [nucleoplasm]' [Requirement:R-HSA-182825] Requirement by 'FEN1 [nucleoplasm]'
relatedSpecies	[Species:164493] Human immunodeficiency virus 1
releaseDate	2006-11-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:188936] Hughes, SH, 2006-10-30 22:00:51
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-182876
summation	[Summation:182811] The fate of the discontinuous viral DNA duplex synthesized i...
updateTrackers	[UpdateTracker:9784474] Update Tracker - [Reaction:182876] Removal of plus-strand flap and gap closure complete synthesis of linear duplex viral DNA - v54:[addLiteratureReference]

Referrals

(updatedInstance)	[UpdateTracker:9784474] Update Tracker - [Reaction:182876] Removal of plus-strand flap and gap closure complete synthesis of linear duplex viral DNA - v54:[addLiteratureReference]
(hasEvent)	[Pathway:R-HSA-162594] Early Phase of HIV Life Cycle
(precedingEvent)	[Reaction:R-HSA-8951690] Formation of RTC with integration competent viral DNA:BANF1:HMGA1:PSIP1

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