Removal of plus-strand flap and gap closure complete synthesis of linear duplex viral DNA

Stable Identifier
R-HSA-182876
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Human immunodeficiency virus 1
Compartment
nucleoplasm
ReviewStatus
5/5
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Removal of plus-strand flap and gap closure complete synthesis of linear duplex viral DNA
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The fate of the discontinuous viral DNA duplex synthesized in the cytosol of an infected cell by HIV-1 reverse transcriptase is not entirely clear. Studies of some viral systems suggest that this discontinuous structure is required for passage of the viral duplex DNA into the nucleus while there are evidence contrary to this observation. Studies in vitro indicate that human nuclear flap endonuclease and DNA ligase can remove the flap and seal the plus-strand discontinuity in HIV-1 DNA (Miller et al. 1995; Rausch and Le Grice 2004; Rumbaugh et al. 1998), although role of flap is not yet clear.
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Output
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as an event of
Event Information
Go Biological Process
RNA-templated DNA biosynthetic process (0006278)
This event is regulated
Requirements
Disease
Name Identifier Synonyms
Human immunodeficiency virus infectious disease DOID:526 HIV infection
Cross References
Mondo
Authored
Gopinathrao, G  (2006-05-19)
D'Eustachio, P  (2006-05-19)
Reviewed
Hughes, SH  (2006-10-31)
Created
Gopinathrao, G  (2006-07-19)
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