Reactome | ZBP1(DAI) recruits RIP1 and RIP3

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ZBP1(DAI) recruits RIP1 and RIP3 Show undefined attributes

authored	[InstanceEdit:1606299] Shamovsky, V, 2011-09-21
category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:1810475] Shamovsky, V, 2011-10-25
dbId	1810457
displayName	ZBP1(DAI) recruits RIP1 and RIP3
edited	[InstanceEdit:2134527] Shamovsky, V, 2012-02-23
eventOf	[Pathway:R-HSA-1810476] RIP-mediated NFkB activation via ZBP1 - Homo sapiens
followingEvent	[Reaction:R-HSA-168910] RIP1 facilitates IKK complex phosphorylation - Homo sapiens
input	[Complex:R-HSA-1591233] dsDNA:ZBP1 [cytosol] [EntityWithAccessionedSequence:R-HSA-168651] RIPK1 [cytosol] [EntityWithAccessionedSequence:R-HSA-450328] RIPK3 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1606323] DAI/ZBP1 recruits RIP1 and RIP3 through RIP homotypic interaction motifs to activate NF-kappaB [LiteratureReference:1606325] Receptor-interacting protein homotypic interaction motif-dependent control of NF-kappa B activation via the DNA-dependent activator of IFN regulatory factors
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	ZBP1(DAI) recruits RIP1 and RIP3
output	[Complex:R-HSA-1810470] dsDNA:ZBP1:RIP1:RIP3 [cytosol]
precedingEvent	[Reaction:R-HSA-1591234] ZBP1 binds cytosolic DNA - Homo sapiens
relatedSpecies	[Species:8982084] Human alphaherpesvirus 2 [Species:2671791] Human cytomegalovirus
releaseDate	2012-03-13
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2023355] D'Eustachio, P, 2011-12-07 [InstanceEdit:2129340] Upton, JW, Mocarski, ES, 2012-02-19
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1810457
summation	[Summation:1810456] Two RIP homotypic interaction motifs (RHIM) were identified ...

Referrals

(hasEvent)	[Pathway:R-HSA-1810476] RIP-mediated NFkB activation via ZBP1
(precedingEvent)	[Reaction:R-HSA-168910] RIP1 facilitates IKK complex phosphorylation

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