Reactome | UGTs transfer GlcA from UDP-GlcA to O-centre substrates

Schema > Reaction > Entries

UGTs transfer GlcA from UDP-GlcA to O-centre substrates Show undefined attributes

authored	[InstanceEdit:174926] Jassal, B, 2006-02-23 09:32:09
catalystActivity	[CatalystActivity:174915] glucuronosyltransferase activity of UGTs (O-GlcA forming) [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:17957] endoplasmic reticulum lumen [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:174926] Jassal, B, 2006-02-23 09:32:09
dbId	174931
displayName	UGTs transfer GlcA from UDP-GlcA to O-centre substrates
edited	[InstanceEdit:174926] Jassal, B, 2006-02-23 09:32:09
eventOf	[Pathway:R-HSA-156588] Glucuronidation - Homo sapiens [Pathway:R-HSA-9749641] Aspirin ADME - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-9757459] ST metabolites diffuse out of ER lumen - Homo sapiens
input	[DefinedSet:R-ALL-174911] O-centre functional group substrate [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-174384] UDP-GlcA [endoplasmic reticulum lumen]
isInDisease	false
isInferred	false
literatureReference	[Book:76380] 9780071470513 Parkinson, A Casarett and Doull's Toxicology 5th Edn [LiteratureReference:158728] Glucuronide conjugates of 4-aminobiphenyl and its N-hydroxy metabolites. pH stability and synthesis by human and dog liver. [LiteratureReference:9749993] Glucuronidation of the aspirin metabolite salicylic acid by expressed UDP-glucuronosyltransferases and human liver microsomes
maxDepth	1
modified	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
name	UGTs transfer GlcA from UDP-GlcA to O-centre substrates
orthologousEvent	[Reaction:R-RNO-174931] UGTs transfer GlcA from UDP-GlcA to O-centre substrates - Rattus norvegicus [Reaction:R-MMU-174931] UGTs transfer GlcA from UDP-GlcA to O-centre substrates - Mus musculus
output	[DefinedSet:R-ALL-174914] O-glucuronide [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-158602] UDP [endoplasmic reticulum lumen]
precedingEvent	[Reaction:R-HSA-174368] SLC35D1 hexamer transports UDP-GlcA, UDP-GlcNAc from cytosol to endoplasmic reticulum lumen - Homo sapiens [Reaction:R-HSA-76373] N-hydroxylation of 4-aminobiphenyl - Homo sapiens [Reaction:R-HSA-9749792] CES1,CES2 hydrolyze ASA- to ST - Homo sapiens [BlackBoxEvent:R-HSA-9757451] ASA-,ST translocate from cytosol to ER lumen of hepatocytes - Homo sapiens
releaseDate	2005-06-13
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:351775] D'Eustachio, P, 2008-05-28 08:30:54 [InstanceEdit:8954302] D'Eustachio, Peter, 2017-01-06
revised	[InstanceEdit:8942176] Jassal, Bijay, 2016-10-10
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-174931
summation	[Summation:176097] Typical O-centred substrates were chosen as examples for the...
updateTrackers	[UpdateTracker:9775535] Update Tracker - [Reaction:174931] UGTs transfer GlcA from UDP-GlcA to O-centre substrates - v78:[addLiteratureReference, modifyText] [UpdateTracker:9781869] Update Tracker - [Reaction:174931] UGTs transfer GlcA from UDP-GlcA to O-centre substrates - v60:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9775535] Update Tracker - [Reaction:174931] UGTs transfer GlcA from UDP-GlcA to O-centre substrates - v78:[addLiteratureReference, modifyText] [UpdateTracker:9781869] Update Tracker - [Reaction:174931] UGTs transfer GlcA from UDP-GlcA to O-centre substrates - v60:[modifyText]
(hasEvent)	[Pathway:R-HSA-9749641] Aspirin ADME [Pathway:R-HSA-156588] Glucuronidation
(precedingEvent)	[BlackBoxEvent:R-HSA-9757459] ST metabolites diffuse out of ER lumen