UGTs transfer GlcA from UDP-GlcA to O-centre substrates

Stable Identifier
R-HSA-174931
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Typical O-centred substrates were chosen as examples for these isozymes. Many UDP-glucuronosyltransferases (UGTs) can transfer the glucuronyl moiety (GlcA) from UDP-GlcA to the O-centre functional group of many substrates to form 4-O-glucuronides (Casarett & Doull 1995, Babu et al. 1996).

Literature References
PubMed ID Title Journal Year
8687483 Glucuronide conjugates of 4-aminobiphenyl and its N-hydroxy metabolites. pH stability and synthesis by human and dog liver.

Babu, SR, Lakshmi, VM, Huang, GP, Zenser, TV, Davis, BB

Biochem Pharmacol 1996
  Casarett and Doull's Toxicology 5th Edn

Parkinson, A

  1995
Participants
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
glucuronosyltransferase activity of UGTs (O-GlcA forming) [endoplasmic reticulum membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created
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