Reactome | RFC binding displaces Pol Alpha on the C-strand of the telomere

Schema > Reaction > Entries

RFC binding displaces Pol Alpha on the C-strand of the telomere Show undefined attributes

category	dissociation
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10346782
displayName	RFC binding displaces Pol Alpha on the C-strand of the telomere
eventOf	[Pathway:R-BTA-174411] Polymerase switching on the C-strand of the telomere - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-BTA-174439] Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere - Bos taurus
goBiologicalProcess	[GO_BiologicalProcess:263978] telomere maintenance via semi-conservative replication
inferredFrom	[Reaction:R-HSA-174452] RFC binding displaces Pol Alpha on the C-strand of the telomere - Homo sapiens
input	[CandidateSet:R-BTA-9668941] RFC,(CFT18-RFC) [nucleoplasm] [Complex:R-BTA-174433] RNA primer:DNA primer:G-strand extended telomere:POLA:primase [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	RFC binding displaces Pol Alpha on the C-strand of the telomere
output	[Complex:R-BTA-9668830] CST complex [nucleoplasm] [Complex:R-BTA-68507] DNA polymerase alpha:primase [nucleoplasm] [Complex:R-BTA-174454] RFC Heteropentamer:RNA primer-DNA primer:G-strand extended telomere end [nucleoplasm]
precedingEvent	[Reaction:R-BTA-174427] The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere - Bos taurus [Reaction:R-BTA-9668902] Formation of the CTF18-RFC(7s) complex - Bos taurus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-174452
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-174411] Polymerase switching on the C-strand of the telomere
(precedingEvent)	[Reaction:R-BTA-174439] Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere
(inferredTo)	[Reaction:R-HSA-174452] RFC binding displaces Pol Alpha on the C-strand of the telomere

Cite Us!