Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
Schema
>
Reaction
>
Entries
The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere
Show undefined attributes
Go to Details
authored
[InstanceEdit:176728] Blackburn, EH, Seidel, J, 2006-03-09 19:41:08
catalystActivity
[CatalystActivity:9668816] DNA-directed 5'-3' RNA polymerase activity of POLA:primase:G-strand extended telomere end [nucleoplasm]
category
transition
compartment
[Compartment:7660] nucleoplasm
created
[InstanceEdit:174426] Gillespie, ME, 2006-02-17 17:57:39
dbId
174425
displayName
The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere
edited
[InstanceEdit:9686480] Orlic-Milacic, Marija, 2020-05-04
eventOf
[Pathway:R-HSA-174430] Telomere C-strand synthesis initiation - Homo sapiens
followingEvent
[Reaction:R-HSA-174427] The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere - Homo sapiens
goBiologicalProcess
[GO_BiologicalProcess:263978] telomere maintenance via semi-conservative replication
input
[SimpleEntity:R-ALL-9757634] NTP [nucleoplasm]
[Complex:R-HSA-9668602] POLA:primase:G-strand extended telomere end [nucleoplasm]
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:69330] DNA primase from KB cells. Characterization of a primase activity tightly associated with immunoaffinity-purified DNA polymerase-alpha
[LiteratureReference:9668848] CTC1-STN1 terminates telomerase while STN1-TEN1 enables C-strand synthesis during telomere replication in colon cancer cells
[LiteratureReference:9668860] Alterations of DNA and chromatin structures at telomeres and genetic instability in mouse cells defective in DNA polymerase alpha
modified
[InstanceEdit:10560457] Wright, Adam, 2024-03-07
name
The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere
negativePrecedingEvent
[NegativePrecedingEvent:9766487] Futile Cycle: RFC binding displaces Pol Alpha on the C-strand of the telomere
orthologousEvent
[Reaction:R-GGA-174425] The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere - Gallus gallus
[Reaction:R-SSC-174425] The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere - Sus scrofa
[Reaction:R-BTA-174425] The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere - Bos taurus
[Reaction:R-CFA-174425] The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere - Canis familiaris
[Reaction:R-RNO-174425] The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere - Rattus norvegicus
[Reaction:R-MMU-174425] The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere - Mus musculus
output
[Complex:R-HSA-174434] RNA primer:G-strand extended telomere end:POLA:primase [nucleoplasm]
precedingEvent
[Reaction:R-HSA-9668831] CST complex formation - Homo sapiens
[Reaction:R-HSA-9668597] DNA polymerase:primase binds G-strand of the telomere - Homo sapiens
regulatedBy
[PositiveRegulation:9668852] Positive regulation by 'CST complex [nucleoplasm]'
releaseDate
2005-06-13
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:182786] Price, C, 2006-07-13 18:33:38
[InstanceEdit:9686481] Hayashi, Makoto T, 2020-04-29
revised
[InstanceEdit:9668855] Orlic-Milacic, Marija, 2019-11-29
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-174425
summation
[Summation:211342] The complementary C-strand at telomeres is synthesized by th...
Referrals
(hasEvent)
[Pathway:R-HSA-174430] Telomere C-strand synthesis initiation
(precedingEvent)
[Reaction:R-HSA-174427] The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text