Reactome | The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere

Schema > Reaction > Entries

The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere Show undefined attributes

catalystActivity	[CatalystActivity:10329286] DNA-directed 5'-3' RNA polymerase activity of POLA:primase:G-strand extended telomere end [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10314670] Wright, Adam, 2024-03-07
dbId	10329288
displayName	The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere
eventOf	[Pathway:R-SSC-174430] Telomere C-strand synthesis initiation - Sus scrofa
evidenceType	[EvidenceType:9864366] inferred by electronic annotation
followingEvent	[Reaction:R-SSC-174427] The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere - Sus scrofa
goBiologicalProcess	[GO_BiologicalProcess:263978] telomere maintenance via semi-conservative replication
inferredFrom	[Reaction:R-HSA-174425] The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere - Homo sapiens
input	[SimpleEntity:R-ALL-9757634] NTP [nucleoplasm] [Complex:R-SSC-9668602] POLA:primase:G-strand extended telomere end [nucleoplasm]
isInDisease	false
isInferred	true
name	The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere
output	[Complex:R-SSC-174434] RNA primer:G-strand extended telomere end:POLA:primase [nucleoplasm]
precedingEvent	[Reaction:R-SSC-9668831] CST complex formation - Sus scrofa [Reaction:R-SSC-9668597] DNA polymerase:primase binds G-strand of the telomere - Sus scrofa
regulatedBy	[PositiveRegulation:10329289] Positive regulation by 'CST complex [nucleoplasm]'
releaseDate	2024-03-27
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-174425
summation	[Summation:9864365] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-174430] Telomere C-strand synthesis initiation
(precedingEvent)	[Reaction:R-SSC-174427] The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere
(inferredTo)	[Reaction:R-HSA-174425] The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere

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