The complementary C-strand at telomeres is synthesized by the DNA polymerase alpha:primase complex (Nakamura et al. 2005) using conventional RNA priming (Wang et al. 1984). Interaction of the DNA polymerase alpha complex with the G-strand-bound CST complex is needed for successful priming of the C-strand (Feng et al. 2018).
Mizuno, T, Nakamura, M, Ishikawa, F, Nabetani, A, Hanaoka, F
Diao, J, Price, CM, Feng, X, Bhattacharjee, A, Hsu, SJ, Wang, Y
Hu, SZ, Korn, D, Wang, TS
DNA-directed 5'-3' RNA polymerase activity of POLA:primase:G-strand extended telomere end [nucleoplasm]
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