Reactome | Phosphorylation of the Emi1 DSGxxS degron by Plk1

Schema > Reaction > Entries

Phosphorylation of the Emi1 DSGxxS degron by Plk1 Show undefined attributes

authored	[InstanceEdit:174241] Lorca, T, Castro, A, 2006-01-26 00:00:00
catalystActivity	[CatalystActivity:156714] protein serine/threonine kinase activity of p-T210-PLK1 [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:174149] Matthews, L, 2006-02-17 00:41:48
dbId	174174
displayName	Phosphorylation of the Emi1 DSGxxS degron by Plk1
edited	[InstanceEdit:174297] Matthews, L, 2006-02-17 05:22:55
eventOf	[Pathway:R-HSA-176417] Phosphorylation of Emi1 - Homo sapiens
followingEvent	[Reaction:R-HSA-174209] Phosphorylated Emi1 binds the beta-TrCP in the SCF complex - Homo sapiens
input	2 × [SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [Complex:R-HSA-188679] Emi1:Cdc20/Cdh1 complex [nucleoplasm]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:163011] Plk1 regulates activation of the anaphase promoting complex by phosphorylating and triggering SCFbetaTrCP-dependent destruction of the APC Inhibitor Emi1
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	Phosphorylation of the Emi1 DSGxxS degron by Plk1
orthologousEvent	[Reaction:R-DME-174174] Phosphorylation of the Emi1 DSGxxS degron by Plk1 - Drosophila melanogaster [Reaction:R-GGA-174174] Phosphorylation of the Emi1 DSGxxS degron by Plk1 - Gallus gallus [Reaction:R-XTR-174174] Phosphorylation of the Emi1 DSGxxS degron by Plk1 - Xenopus tropicalis [Reaction:R-DRE-174174] Phosphorylation of the Emi1 DSGxxS degron by Plk1 - Danio rerio [Reaction:R-SSC-174174] Phosphorylation of the Emi1 DSGxxS degron by Plk1 - Sus scrofa [Reaction:R-BTA-174174] Phosphorylation of the Emi1 DSGxxS degron by Plk1 - Bos taurus [Reaction:R-CFA-174174] Phosphorylation of the Emi1 DSGxxS degron by Plk1 - Canis familiaris [Reaction:R-RNO-174174] Phosphorylation of the Emi1 DSGxxS degron by Plk1 - Rattus norvegicus [Reaction:R-MMU-174174] Phosphorylation of the Emi1 DSGxxS degron by Plk1 - Mus musculus
output	2 × [SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [Complex:R-HSA-176446] phospho-Emi1(Ser 145, Ser 149):Cdc20/Cdh1 complexes [nucleoplasm]
precedingEvent	[Reaction:R-HSA-174235] Association of Emi1 with Cdc20 - Homo sapiens [Reaction:R-HSA-174097] Association of Emi1 with Cdh1 - Homo sapiens
releaseDate	2006-04-24
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:177300] Peters, JM, 2006-03-27 22:55:09
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-174174
summation	[Summation:176441] The phosphorylation of Emi1 by Plk1 is believed to be involv...

Referrals

(hasEvent)	[Pathway:R-HSA-176417] Phosphorylation of Emi1
(precedingEvent)	[Reaction:R-HSA-174209] Phosphorylated Emi1 binds the beta-TrCP in the SCF complex