Reactome | Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2

Schema > Reaction > Entries

Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2 Show undefined attributes

authored	[InstanceEdit:174241] Lorca, T, Castro, A, 2006-01-26 00:00:00
catalystActivity	[CatalystActivity:174240] cyclin-dependent protein serine/threonine kinase activity of CCNB1:p-T161-CDK1 [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:174149] Matthews, L, 2006-02-17 00:41:48
dbId	174122
displayName	Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2
edited	[InstanceEdit:174291] Matthews, L, 2006-02-17 05:21:42
eventOf	[Pathway:R-HSA-176417] Phosphorylation of Emi1 - Homo sapiens
followingEvent	[Reaction:R-HSA-174209] Phosphorylated Emi1 binds the beta-TrCP in the SCF complex - Homo sapiens
input	[SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [Complex:R-HSA-188679] Emi1:Cdc20/Cdh1 complex [nucleoplasm]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:174253] Prophase destruction of Emi1 by the SCF(betaTrCP/Slimb) ubiquitin ligase activates the anaphase promoting complex to allow progression beyond prometaphase
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2
orthologousEvent	[Reaction:R-DME-174122] Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2 - Drosophila melanogaster [Reaction:R-XTR-174122] Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2 - Xenopus tropicalis [Reaction:R-DRE-174122] Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2 - Danio rerio [Reaction:R-SSC-174122] Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2 - Sus scrofa [Reaction:R-BTA-174122] Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2 - Bos taurus [Reaction:R-CFA-174122] Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2 - Canis familiaris [Reaction:R-RNO-174122] Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2 - Rattus norvegicus [Reaction:R-MMU-174122] Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2 - Mus musculus
output	[SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [Complex:R-HSA-186975] Phospho-Emi1(Ser 182):Cdc20/Cdh1 complexes [nucleoplasm]
precedingEvent	[Reaction:R-HSA-174235] Association of Emi1 with Cdc20 - Homo sapiens [Reaction:R-HSA-174097] Association of Emi1 with Cdh1 - Homo sapiens [Reaction:R-HSA-170153] Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases - Homo sapiens
releaseDate	2005-06-13
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:177300] Peters, JM, 2006-03-27 22:55:09
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-174122
summation	[Summation:176442] Emi1 is also believed to be phosphorylated by Cyclin B:Cdc2 ...
updateTrackers	[UpdateTracker:9782040] Update Tracker - [Reaction:174122] Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2 - v59:[modifyText] [UpdateTracker:9789672] Update Tracker - [Reaction:174122] Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2 - v37:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9782040] Update Tracker - [Reaction:174122] Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2 - v59:[modifyText] [UpdateTracker:9789672] Update Tracker - [Reaction:174122] Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2 - v37:[modifyText]
(hasEvent)	[Pathway:R-HSA-176417] Phosphorylation of Emi1
(precedingEvent)	[Reaction:R-HSA-174209] Phosphorylated Emi1 binds the beta-TrCP in the SCF complex