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Association of Cyclin B:Cdc2 with Cdc20:APC/C complex
Stable Identifier
R-HSA-174120
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
Regulation of mitotic cell cycle (Homo sapiens)
APC/C-mediated degradation of cell cycle proteins (Homo sapiens)
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins (Homo sapiens)
APC/C:Cdc20 mediated degradation of mitotic proteins (Homo sapiens)
APC/C:Cdc20 mediated degradation of Cyclin B (Homo sapiens)
Association of Cyclin B:Cdc2 with Cdc20:APC/C complex (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Cyclin B is believed to be recognized by the APC/C:Cdc20 complex through its D-box sequence.
Literature References
PubMed ID
Title
Journal
Year
11285280
Anaphase-promoting complex/cyclosome-dependent proteolysis of human cyclin A starts at the beginning of mitosis and is not subject to the spindle assembly checkpoint
Peters, JM
,
Gannon, J
,
Geley, S
,
Kramer, E
,
Gieffers, C
,
Hunt, T
J Cell Biol
2001
Participants
Input
CCNB1:p-T161-CDK1 [cytosol]
(Homo sapiens)
CDC20:p-APC/C [cytosol]
(Homo sapiens)
Output
Cdc20:phospho-APC/C:Cyclin B:Cdc2 complex [cytosol]
(Homo sapiens)
Participates
as an event of
APC/C:Cdc20 mediated degradation of Cyclin B (Homo sapiens)
Orthologous Events
Association of Cyclin B:Cdc2 with Cdc20:APC/C complex (Bos taurus)
Association of Cyclin B:Cdc2 with Cdc20:APC/C complex (Canis familiaris)
Association of Cyclin B:Cdc2 with Cdc20:APC/C complex (Drosophila melanogaster)
Association of Cyclin B:Cdc2 with Cdc20:APC/C complex (Mus musculus)
Association of Cyclin B:Cdc2 with Cdc20:APC/C complex (Rattus norvegicus)
Association of Cyclin B:Cdc2 with Cdc20:APC/C complex (Sus scrofa)
Association of Cyclin B:Cdc2 with Cdc20:APC/C complex (Xenopus tropicalis)
Authored
Castro, A (2006-01-26)
Lorca, T (2006-01-26)
Reviewed
Peters, JM (2006-03-28)
Created
Matthews, L (2006-02-17)
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