Reactome | Multiubiquitination of APC/C-associated Cdh1

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Multiubiquitination of APC/C-associated Cdh1 Show undefined attributes

authored	[InstanceEdit:174241] Lorca, T, Castro, A, 2006-01-26 00:00:00
catalystActivity	[CatalystActivity:174085] ubiquitin-protein transferase activity of phospho-Cdh1:phospho-APC/C complex [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:174149] Matthews, L, 2006-02-17 00:41:48
dbId	174057
displayName	Multiubiquitination of APC/C-associated Cdh1
edited	[InstanceEdit:174291] Matthews, L, 2006-02-17 05:21:42
eventOf	[Pathway:R-HSA-174084] Autodegradation of Cdh1 by Cdh1:APC/C - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-174058] Degradation of multiubiquitinated Cdh1 - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:7441] ubiquitin-dependent protein catabolic process
input	[Complex:R-HSA-174167] phospho-Cdh1:phospho-APC/C complex [nucleoplasm] 3 × [DefinedSet:R-HSA-68524] Ub [nucleoplasm]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:176906] Mammalian Cdh1/Fzr mediates its own degradation
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	Multiubiquitination of APC/C-associated Cdh1
negativePrecedingEvent	[NegativePrecedingEvent:9764082] Futile Cycle: APC/C:Cdh1-mediated degradation of Skp2 [NegativePrecedingEvent:9764085] Futile Cycle: Degradation of multiubiquitinated Cdh1
orthologousEvent	[Reaction:R-DDI-174057] Multiubiquitination of APC/C-associated Cdh1 - Dictyostelium discoideum [Reaction:R-DME-174057] Multiubiquitination of APC/C-associated Cdh1 - Drosophila melanogaster [Reaction:R-GGA-174057] Multiubiquitination of APC/C-associated Cdh1 - Gallus gallus [Reaction:R-XTR-174057] Multiubiquitination of APC/C-associated Cdh1 - Xenopus tropicalis [Reaction:R-DRE-174057] Multiubiquitination of APC/C-associated Cdh1 - Danio rerio [Reaction:R-SSC-174057] Multiubiquitination of APC/C-associated Cdh1 - Sus scrofa [Reaction:R-BTA-174057] Multiubiquitination of APC/C-associated Cdh1 - Bos taurus [Reaction:R-CFA-174057] Multiubiquitination of APC/C-associated Cdh1 - Canis familiaris [Reaction:R-RNO-174057] Multiubiquitination of APC/C-associated Cdh1 - Rattus norvegicus [Reaction:R-MMU-174057] Multiubiquitination of APC/C-associated Cdh1 - Mus musculus
output	[Complex:R-HSA-174068] multiubiquitinated Cdh1 associated with APC/C [nucleoplasm]
precedingEvent	[Reaction:R-HSA-174195] Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex - Homo sapiens
releaseDate	2006-04-24
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:177300] Peters, JM, 2006-03-27 22:55:09
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-174057
summation	[Summation:177321] Cdh1 is multiubiquitinated by the APC/C:Cdh1 complex prior t...

Referrals

(hasEvent)	[Pathway:R-HSA-174084] Autodegradation of Cdh1 by Cdh1:APC/C
(precedingEvent)	[BlackBoxEvent:R-HSA-174058] Degradation of multiubiquitinated Cdh1