Factor B binds to C3(H2O)

Stable Identifier
R-HSA-173740
Type
Reaction [binding]
Species
Homo sapiens
Compartment
extracellular region
ReviewStatus
5/5
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Factor B binds to C3(H2O)
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Thioester bond hydrolysis causes conformational rearrangements that give C3(H2O) the ability to bind Factor B (Schreiber et al. 1978). The spontaneous hydrolysis rate of C3 under physiological conditions and temperature is about l% per hour, thus the C3b-like properties of C3(H2O) provide a continuous low level initiation of the alternative pathway of complement activation (Pangburn & Muller-Eberhard 1983).
Literature References
PubMed ID Title Journal Year
279011 Initiation of the alternative pathway of complement: recognition of activators by bound C3b and assembly of the entire pathway from six isolated proteins

Schreiber, RD, Pangburn, MK, Muller-Eberhard, HJ, Lesavre, PH

Proc Natl Acad Sci U S A 1978
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Orthologous Events
Factor B binds to C3(H2O) (Bos taurus)
Factor B binds to C3(H2O) (Canis familiaris)
Factor B binds to C3(H2O) (Danio rerio)
Factor B binds to C3(H2O) (Gallus gallus)
Factor B binds to C3(H2O) (Mus musculus)
Factor B binds to C3(H2O) (Sus scrofa)
Factor B binds to C3(H2O) (Xenopus tropicalis)
Complement factor B binds to the hydrolyzed form of C3 (Gallus gallus)
Authored
de Bono, B  (2004-08-04)
Reviewed
D'Eustachio, P  (2006-07-04)
Created
de Bono, B  (2006-02-16)
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