Reactome | UDP-glucose is oxidised to UDP-glucuronate

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UDP-glucose is oxidised to UDP-glucuronate Show undefined attributes

authored	[InstanceEdit:173596] Jassal, Bijay, 2006-02-14
catalystActivity	[CatalystActivity:173601] UDP-glucose 6-dehydrogenase activity of 6xUGDH [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:173596] Jassal, Bijay, 2006-02-14
crossReference	[DatabaseIdentifier:12668022] RHEA:23597 [DatabaseIdentifier:9912873] RHEA:23597
dbId	173597
displayName	UDP-glucose is oxidised to UDP-glucuronate
edited	[InstanceEdit:173596] Jassal, Bijay, 2006-02-14
eventOf	[Pathway:R-HSA-173599] Formation of the active cofactor, UDP-glucuronate - Homo sapiens
followingEvent	[Reaction:R-HSA-174368] SLC35D1 hexamer transports UDP-GlcA, UDP-GlcNAc from cytosol to endoplasmic reticulum lumen - Homo sapiens [Polymerisation:R-HSA-2160851] HAS1,2,3 mediate the polymerization and export of HA - Homo sapiens
input	[SimpleEntity:R-ALL-29356] H2O [cytosol] 2 × [SimpleEntity:R-ALL-29360] NAD+ [cytosol] [SimpleEntity:R-ALL-29410] UDP-Glc [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:266226] Characterization of human UDP-glucose dehydrogenase. CYS-276 is required for the second of two successive oxidations
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	UDP-glucose is oxidised to UDP-glucuronate H2O + 2 NAD(+) + UDP-alpha-D-glucose => 3 H(+) + 2 NADH + UDP-alpha-D-glucuronate
orthologousEvent	[Reaction:R-CEL-173597] UDP-glucose is oxidised to UDP-glucuronate - Caenorhabditis elegans [Reaction:R-DME-173597] UDP-glucose is oxidised to UDP-glucuronate - Drosophila melanogaster [Reaction:R-GGA-173597] UDP-glucose is oxidised to UDP-glucuronate - Gallus gallus [Reaction:R-XTR-173597] UDP-glucose is oxidised to UDP-glucuronate - Xenopus tropicalis [Reaction:R-DRE-173597] UDP-glucose is oxidised to UDP-glucuronate - Danio rerio [Reaction:R-SSC-173597] UDP-glucose is oxidised to UDP-glucuronate - Sus scrofa [Reaction:R-BTA-173597] UDP-glucose is oxidised to UDP-glucuronate - Bos taurus [Reaction:R-CFA-173597] UDP-glucose is oxidised to UDP-glucuronate - Canis familiaris [Reaction:R-RNO-173597] UDP-glucose is oxidised to UDP-glucuronate - Rattus norvegicus [Reaction:R-MMU-173597] UDP-glucose is oxidised to UDP-glucuronate - Mus musculus
output	3 × [SimpleEntity:R-ALL-70106] H+ [cytosol] 2 × [SimpleEntity:R-ALL-73473] NADH [cytosol] [SimpleEntity:R-ALL-158601] UDP-GlcA [cytosol]
precedingEvent	[Reaction:R-HSA-70286] UTP + D-glucose 1-phosphate => pyrophosphate + UDP-glucose - Homo sapiens
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2010-06-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:351775] D'Eustachio, P, 2008-05-28 08:30:54 [InstanceEdit:9916041] Hill, David P, 2024-07-19
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-173597
summation	[Summation:179286] UDP-glucose dehydrogenase (UGDH) catalyzes the conversion of...
updateTrackers	[UpdateTracker:9791580] Update Tracker - [Reaction:173597] UDP-glucose is oxidised to UDP-glucuronate - v28:[addOutput] [UpdateTracker:9791916] Update Tracker - [Reaction:173597] UDP-glucose is oxidised to UDP-glucuronate - v25:[addLiteratureReference, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9791580] Update Tracker - [Reaction:173597] UDP-glucose is oxidised to UDP-glucuronate - v28:[addOutput] [UpdateTracker:9791916] Update Tracker - [Reaction:173597] UDP-glucose is oxidised to UDP-glucuronate - v25:[addLiteratureReference, modifyText]
(hasEvent)	[Pathway:R-HSA-173599] Formation of the active cofactor, UDP-glucuronate
(precedingEvent)	[Polymerisation:R-HSA-2160851] HAS1,2,3 mediate the polymerization and export of HA [Reaction:R-HSA-174368] SLC35D1 hexamer transports UDP-GlcA, UDP-GlcNAc from cytosol to endoplasmic reticulum lumen