Reactome | UDP-glucose is oxidised to UDP-glucuronate

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UDP-glucose is oxidised to UDP-glucuronate Show undefined attributes

catalystActivity	[CatalystActivity:10118251] UDP-glucose 6-dehydrogenase activity of 6xUGDH [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10118253
displayName	UDP-glucose is oxidised to UDP-glucuronate
eventOf	[Pathway:R-RNO-173599] Formation of the active cofactor, UDP-glucuronate - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-174368] SLC35D1 hexamer transports UDP-GlcA, UDP-GlcNAc from cytosol to endoplasmic reticulum lumen - Rattus norvegicus [Polymerisation:R-RNO-2160851] HAS1,2,3 mediate the polymerization and export of HA - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-173597] UDP-glucose is oxidised to UDP-glucuronate - Homo sapiens
input	[SimpleEntity:R-ALL-29356] H2O [cytosol] 2 × [SimpleEntity:R-ALL-29360] NAD+ [cytosol] [SimpleEntity:R-ALL-29410] UDP-Glc [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	UDP-glucose is oxidised to UDP-glucuronate H2O + 2 NAD(+) + UDP-alpha-D-glucose => 3 H(+) + 2 NADH + UDP-alpha-D-glucuronate
output	3 × [SimpleEntity:R-ALL-70106] H+ [cytosol] 2 × [SimpleEntity:R-ALL-73473] NADH [cytosol] [SimpleEntity:R-ALL-158601] UDP-GlcA [cytosol]
precedingEvent	[Reaction:R-RNO-70286] UTP + D-glucose 1-phosphate => pyrophosphate + UDP-glucose - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-173597
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-173599] Formation of the active cofactor, UDP-glucuronate
(precedingEvent)	[Polymerisation:R-RNO-2160851] HAS1,2,3 mediate the polymerization and export of HA [Reaction:R-RNO-174368] SLC35D1 hexamer transports UDP-GlcA, UDP-GlcNAc from cytosol to endoplasmic reticulum lumen
(inferredTo)	[Reaction:R-HSA-173597] UDP-glucose is oxidised to UDP-glucuronate

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