Reactome | FRS2 binds to active TrkA receptor

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FRS2 binds to active TrkA receptor Show undefined attributes

category	binding
compartment	[Compartment:74700] endosome membrane
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10571316
displayName	FRS2 binds to active TrkA receptor
eventOf	[Pathway:R-DRE-170968] Frs2-mediated activation - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DRE-170977] FRS2 is phosphorylated by active TrkA receptor - Danio rerio
inferredFrom	[Reaction:R-HSA-170964] FRS2 binds to active TrkA receptor - Homo sapiens
input	[Complex:R-DRE-190083] Activated TrkA receptor complex [endosome membrane] [EntityWithAccessionedSequence:R-DRE-190244] frs2b [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	FRS2 binds to active TrkA receptor
output	[Complex:R-DRE-190068] Active TrkA receptor:FRS2 complex [endosome membrane]
precedingEvent	[BlackBoxEvent:R-DRE-190065] Activated TrkA receptor internalizes to endosomes - Danio rerio
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-170964
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-170968] Frs2-mediated activation
(precedingEvent)	[Reaction:R-DRE-170977] FRS2 is phosphorylated by active TrkA receptor
(inferredTo)	[Reaction:R-HSA-170964] FRS2 binds to active TrkA receptor

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