Reactome | Dimeric TGF-beta-1 binds to the receptor

Dimeric TGF-beta-1 binds to the receptor

Stable Identifier

R-HSA-170861

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

Synonyms

Dimeric TGFB1 binds to TGFBR2 homodimer

ReviewStatus

4/5

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Dimeric TGF-beta-1 binds to the receptor

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The mature dimeric TGF-beta-1 (TGFB1) binds with high affinity to its signaling receptor, the type II receptor serine/threonine kinase (TGFBR2) (Wrana et al. 1992, Moustakas et al. 1993, Franzen et al. 1993). While type II receptor can form dimeric complexes in the absence of TGFB1 when overexpressed, it predominantly exists as a monomer on the surface of unstimulated cells under physiological conditions, and dimerization of TGFBR2 is triggered by TGFB1 binding (Zhang et al. 2009). Also, the binding of TGFBR2 with TGFB1 is further facilitated by TGFBR3, which binds primarily with TGFB2 and facilitates the TGFBR2 ligand binding (Lopez-Casillas et al. 1993). This process is inhibited by the soluble form of TGFBR3 created by MMPs. A soluble form of TGBFR3 retains its ligand binding ability and thus inhibits the binding of TGFB ligands in a competitive manner (Lopez-Casillas et al. 1994).

Literature References

PubMed ID	Title	Journal	Year
8242743	Cloning of a TGF beta type I receptor that forms a heteromeric complex with the TGF beta type II receptor Miyazono, K, Schulz, P, Yamashita, H, Ichijo, H, ten Dijke, P, Heldin, CH, Franzen, P	Cell	1993
7693660	The transforming growth factor beta receptors types I, II, and III form hetero-oligomeric complexes in the presence of ligand O'Connor-McCourt, MD, Lodish, HF, Plamondon, J, Henis, YI, Moustakas, A, Lin, HY	J Biol Chem	1993
19720988	Single-molecule imaging reveals transforming growth factor-beta-induced type II receptor dimerization Jiang, Y, Chen, YG, Wang, Q, Zuo, W, Xiao, Z, Zhang, W, Fang, X, Ma, X	Proc. Natl. Acad. Sci. U.S.A.	2009
1333888	TGF beta signals through a heteromeric protein kinase receptor complex Massague, J, Wrana, JL, Carcamo, J, Laiho, M, Attisano, L, Doody, J, Wang, XF, Zentella, A	Cell	1992