Dimeric TGF-beta-1 binds to the receptor

Stable Identifier
R-HSA-170861
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
Dimeric TGFB1 binds to TGFBR2 homodimer
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The mature dimeric TGF-beta-1 (TGFB1) binds with high affinity to its signaling receptor, the type II receptor serine/threonine kinase (TGFBR2) (Wrana et al. 1992, Moustakas et al. 1993, Franzen et al. 1993). While type II receptor can form dimeric complexes in the absence of TGFB1 when overexpressed, it predominantly exists as a monomer on the surface of unstimulated cells under physiological conditions, and dimerization of TGFBR2 is triggered by TGFB1 binding (Zhang et al. 2009).

Literature References
PubMed ID Title Journal Year
7693660 The transforming growth factor beta receptors types I, II, and III form hetero-oligomeric complexes in the presence of ligand

Moustakas, A, Lin, HY, Henis, YI, Plamondon, J, O'Connor-McCourt, MD, Lodish, HF

J Biol Chem 1993
8242743 Cloning of a TGF beta type I receptor that forms a heteromeric complex with the TGF beta type II receptor

Franzen, P, ten Dijke, P, Ichijo, H, Yamashita, H, Schulz, P, Heldin, CH, Miyazono, K

Cell 1993
19720988 Single-molecule imaging reveals transforming growth factor-beta-induced type II receptor dimerization

Zhang, W, Jiang, Y, Wang, Q, Ma, X, Xiao, Z, Zuo, W, Fang, X, Chen, YG

Proc. Natl. Acad. Sci. U.S.A. 2009
1333888 TGF beta signals through a heteromeric protein kinase receptor complex

Wrana, JL, Attisano, L, Carcamo, J, Zentella, A, Doody, J, Laiho, M, Wang, XF, Massague, J

Cell 1992
Participants
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Catalyst Activity
Catalyst Activity
Title
transforming growth factor beta receptor binding activity of Dimeric TGFB1 [extracellular region]
Physical Entity
Activity
Orthologous Events
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Created