Dimeric TGF-beta-1 binds to the receptor

Stable Identifier
Reaction [binding]
Homo sapiens
Dimeric TGFB1 binds to TGFBR2 homodimer
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The mature dimeric TGF-beta-1 (TGFB1) binds with high affinity to its signaling receptor, the type II receptor serine/threonine kinase (TGFBR2) (Wrana et al. 1992, Moustakas et al. 1993, Franzen et al. 1993). While type II receptor can form dimeric complexes in the absence of TGFB1 when overexpressed, it predominantly exists as a monomer on the surface of unstimulated cells under physiological conditions, and dimerization of TGFBR2 is triggered by TGFB1 binding (Zhang et al. 2009). Also, the binding of TGFBR2 with TGFB1 is further facilitated by TGFBR3, which binds primarily with TGFB2 and facilitates the TGFBR2 ligand binding (Lopez-Casillas et al. 1993). This process is inhibited by the soluble form of TGFBR3 created by MMPs. A soluble form of TGBFR3 retains its ligand binding ability and thus inhibits the binding of TGFB ligands in a competitive manner (Lopez-Casillas et al. 1994).
Literature References
PubMed ID Title Journal Year
8242743 Cloning of a TGF beta type I receptor that forms a heteromeric complex with the TGF beta type II receptor

Miyazono, K, Schulz, P, Yamashita, H, Ichijo, H, ten Dijke, P, Heldin, CH, Franzen, P

Cell 1993
7693660 The transforming growth factor beta receptors types I, II, and III form hetero-oligomeric complexes in the presence of ligand

O'Connor-McCourt, MD, Lodish, HF, Plamondon, J, Henis, YI, Moustakas, A, Lin, HY

J Biol Chem 1993
19720988 Single-molecule imaging reveals transforming growth factor-beta-induced type II receptor dimerization

Jiang, Y, Chen, YG, Wang, Q, Zuo, W, Xiao, Z, Zhang, W, Fang, X, Ma, X

Proc. Natl. Acad. Sci. U.S.A. 2009
1333888 TGF beta signals through a heteromeric protein kinase receptor complex

Massague, J, Wrana, JL, Carcamo, J, Laiho, M, Attisano, L, Doody, J, Wang, XF, Zentella, A

Cell 1992
This event is regulated
Orthologous Events
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