Dimeric TGF-beta-1 binds to the receptor

Stable Identifier
Reaction [binding]
Homo sapiens
Dimeric TGFB1 binds to TGFBR2 homodimer
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The mature dimeric TGF-beta-1 (TGFB1) binds with high affinity to its signaling receptor, the type II receptor serine/threonine kinase (TGFBR2) (Wrana et al. 1992, Moustakas et al. 1993, Franzen et al. 1993). While type II receptor can form dimeric complexes in the absence of TGFB1 when overexpressed, it predominantly exists as a monomer on the surface of unstimulated cells under physiological conditions, and dimerization of TGFBR2 is triggered by TGFB1 binding (Zhang et al. 2009).

Literature References
PubMed ID Title Journal Year
8242743 Cloning of a TGF beta type I receptor that forms a heteromeric complex with the TGF beta type II receptor

Miyazono, K, Schulz, P, Yamashita, H, Ichijo, H, ten Dijke, P, Heldin, CH, Franzen, P

Cell 1993
7693660 The transforming growth factor beta receptors types I, II, and III form hetero-oligomeric complexes in the presence of ligand

O'Connor-McCourt, MD, Lodish, HF, Plamondon, J, Henis, YI, Moustakas, A, Lin, HY

J Biol Chem 1993
19720988 Single-molecule imaging reveals transforming growth factor-beta-induced type II receptor dimerization

Jiang, Y, Chen, YG, Wang, Q, Zuo, W, Xiao, Z, Zhang, W, Fang, X, Ma, X

Proc. Natl. Acad. Sci. U.S.A. 2009
1333888 TGF beta signals through a heteromeric protein kinase receptor complex

Massague, J, Wrana, JL, Carcamo, J, Laiho, M, Attisano, L, Doody, J, Wang, XF, Zentella, A

Cell 1992
Orthologous Events
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