Reactome | CAK phosphorylates CDK1 bound to CCNA

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CAK phosphorylates CDK1 bound to CCNA Show undefined attributes

catalystActivity	[CatalystActivity:69222] protein serine/threonine kinase activity of CAK [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:170086] Matthews, L, 2005-12-23 13:25:53
dbId	170087
displayName	CAK phosphorylates CDK1 bound to CCNA
edited	[InstanceEdit:9929401] Orlic-Milacic, Marija, 2024-11-25
eventOf	[Pathway:R-HSA-69273] Cyclin A/B1/B2 associated events during G2/M transition - Homo sapiens
followingEvent	[Reaction:R-HSA-170156] WEE1 phosphorylates CCNA:CDK1 - Homo sapiens
input	[SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [CandidateSet:R-HSA-170090] CCNA:p-T14-CDK1 [nucleoplasm]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:77499] Effects of phosphorylation by CAK on cyclin binding by CDC2 and CDK2. [LiteratureReference:9928866] Distinct activation pathways confer cyclin-binding specificity on Cdk1 and Cdk2 in human cells [LiteratureReference:9929418] Coupling of T161 and T14 phosphorylations protects cyclin B-CDK1 from premature activation
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	CAK phosphorylates CDK1 bound to CCNA CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes
orthologousEvent	[Reaction:R-MMU-170087] CAK phosphorylates CDK1 bound to CCNA - Mus musculus [Reaction:R-CEL-170087] CAK phosphorylates CDK1 bound to CCNA - Caenorhabditis elegans [Reaction:R-DME-170087] CAK phosphorylates CDK1 bound to CCNA - Drosophila melanogaster [Reaction:R-GGA-170087] CAK phosphorylates CDK1 bound to CCNA - Gallus gallus [Reaction:R-XTR-170087] CAK phosphorylates CDK1 bound to CCNA - Xenopus tropicalis [Reaction:R-SSC-170087] CAK phosphorylates CDK1 bound to CCNA - Sus scrofa [Reaction:R-BTA-170087] CAK phosphorylates CDK1 bound to CCNA - Bos taurus [Reaction:R-RNO-170087] CAK phosphorylates CDK1 bound to CCNA - Rattus norvegicus
output	[SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [CandidateSet:R-HSA-170092] CCNA:p-T14,T161-CDK1 [nucleoplasm]
precedingEvent	[BlackBoxEvent:R-HSA-170088] Translocation of CCNA:p-T14-CDK1 to the nucleus - Homo sapiens
releaseDate	2005-04-11
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9936318] Alwakeel, Alan, 2025-01-02
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-170087
summation	[Summation:170192] Full activity of most CDKs is dependent on CAK mediated phos...
updateTrackers	[UpdateTracker:9939641] Update Tracker - [Reaction:170087] CAK phosphorylates CDK1 bound to CCNA - v92:[modifyText, removeLiteratureReference] [UpdateTracker:9788829] Update Tracker - [Reaction:170087] CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes - v40:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9939641] Update Tracker - [Reaction:170087] CAK phosphorylates CDK1 bound to CCNA - v92:[modifyText, removeLiteratureReference] [UpdateTracker:9788829] Update Tracker - [Reaction:170087] CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes - v40:[modifyText]
(hasEvent)	[Pathway:R-HSA-69273] Cyclin A/B1/B2 associated events during G2/M transition
(precedingEvent)	[Reaction:R-HSA-170156] WEE1 phosphorylates CCNA:CDK1