Reactome | CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes

Schema > Reaction > Entries

CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes Show undefined attributes

catalystActivity	[CatalystActivity:69222] protein serine/threonine kinase activity of CAK [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:170086] Matthews, L, 2005-12-23 13:25:53
dbId	170087
displayName	CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes
eventOf	[Pathway:R-HSA-69273] Cyclin A/B1/B2 associated events during G2/M transition - Homo sapiens
followingEvent	[Reaction:R-HSA-170156] Wee1-mediated phosphorylation of Cyclin A:phospho-Cdc2 complexes - Homo sapiens
input	[SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [Complex:R-HSA-170090] CCNA:p-T14-CDK1 [nucleoplasm]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:77499] Effects of phosphorylation by CAK on cyclin binding by CDC2 and CDK2.
modified	[InstanceEdit:10655440] Wright, Adam, 2024-03-08
name	CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes
orthologousEvent	[Reaction:R-DME-170087] CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes - Drosophila melanogaster [Reaction:R-GGA-170087] CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes - Gallus gallus [Reaction:R-XTR-170087] CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes - Xenopus tropicalis [Reaction:R-SSC-170087] CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes - Sus scrofa [Reaction:R-BTA-170087] CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes - Bos taurus [Reaction:R-CFA-170087] CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes - Canis familiaris [Reaction:R-RNO-170087] CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes - Rattus norvegicus [Reaction:R-MMU-170087] CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes - Mus musculus
output	[SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [Complex:R-HSA-170092] CCNA:p-T14,T161-CDK1 [nucleoplasm]
precedingEvent	[Reaction:R-HSA-170088] Translocation of Cyclin A:phospho-Cdc2 (Thr 14) to the nucleus - Homo sapiens
releaseDate	2005-04-11
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-170087
summation	[Summation:170192] Full activity of most CDKs is dependent on CAK mediated phos...

Referrals

(hasEvent)	[Pathway:R-HSA-69273] Cyclin A/B1/B2 associated events during G2/M transition
(precedingEvent)	[Reaction:R-HSA-170156] Wee1-mediated phosphorylation of Cyclin A:phospho-Cdc2 complexes