Reactome | CAK phosphorylates CDK1 bound to CCNA

Schema > Reaction > Entries

CAK phosphorylates CDK1 bound to CCNA Show undefined attributes

catalystActivity	[CatalystActivity:10345680] protein serine/threonine kinase activity of CAK [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10345696
displayName	CAK phosphorylates CDK1 bound to CCNA
eventOf	[Pathway:R-BTA-69273] Cyclin A/B1/B2 associated events during G2/M transition - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-BTA-170156] WEE1 phosphorylates CCNA:CDK1 - Bos taurus
inferredFrom	[Reaction:R-HSA-170087] CAK phosphorylates CDK1 bound to CCNA - Homo sapiens
input	[SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [CandidateSet:R-BTA-170090] CCNA:p-T14-CDK1 [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	CAK phosphorylates CDK1 bound to CCNA CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes
output	[SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [CandidateSet:R-BTA-170092] CCNA:p-T14,T161-CDK1 [nucleoplasm]
precedingEvent	[BlackBoxEvent:R-BTA-170088] Translocation of CCNA:p-T14-CDK1 to the nucleus - Bos taurus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-170087
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-69273] Cyclin A/B1/B2 associated events during G2/M transition
(precedingEvent)	[Reaction:R-BTA-170156] WEE1 phosphorylates CCNA:CDK1
(inferredTo)	[Reaction:R-HSA-170087] CAK phosphorylates CDK1 bound to CCNA

Cite Us!