Reactome | Conformation change in hemagglutinin freeing the fusion peptide of HA2

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Conformation change in hemagglutinin freeing the fusion peptide of HA2 Show undefined attributes

category	transition
compartment	[Compartment:171907] endosome lumen
created	[InstanceEdit:168327] 2007-04-16 22:35:07
crossReference	[DatabaseIdentifier:12020763] Mondo:0005812
dbId	168324
disease	[Disease:1660558] influenza
displayName	Conformation change in hemagglutinin freeing the fusion peptide of HA2
eventOf	[Pathway:R-HSA-168288] Fusion of the Influenza Virion to the Host Cell Endosome - Homo sapiens
followingEvent	[Reaction:R-HSA-168312] Fusion of the influenza virion HA2 protein transmembrane domain to the host cell endosome membrane - Homo sapiens
input	[Complex:R-FLU-189171] Influenza A Viral Particle [endosome lumen]
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:189373] Membrane fusion mechanisms: the influenza hemagglutinin paradigm and its implications for intracellular fusion
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Conformation change in hemagglutinin freeing the fusion peptide of HA2
output	[Complex:R-FLU-189182] Influenza A Viral Particle With A Fusion Competent HA2 [endosome lumen]
precedingEvent	[Reaction:R-HSA-168285] Clathrin-Mediated Pit Formation And Endocytosis Of The Influenza Virion - Homo sapiens
relatedSpecies	[Species:9031716] Influenza A virus
releaseDate	2006-01-23
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-168324
summation	[Summation:179371] The low pH of the endosome causes the viral HA (hemagglutini...
updateTrackers	[UpdateTracker:9792519] Update Tracker - [Reaction:168324] Conformation change in hemagglutinin freeing the fusion peptide of HA2 - v20:[addLiteratureReference, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9792519] Update Tracker - [Reaction:168324] Conformation change in hemagglutinin freeing the fusion peptide of HA2 - v20:[addLiteratureReference, modifyText]
(hasEvent)	[Pathway:R-HSA-168288] Fusion of the Influenza Virion to the Host Cell Endosome
(precedingEvent)	[Reaction:R-HSA-168312] Fusion of the influenza virion HA2 protein transmembrane domain to the host cell endosome membrane

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