Reactome | Conformation change in hemagglutinin freeing the fusion peptide of HA2

Conformation change in hemagglutinin freeing the fusion peptide of HA2

Stable Identifier

R-HSA-168324

Type

Reaction [transition]

Species

Homo sapiens

Related Species

Influenza A virus

Compartment

endosome lumen

ReviewStatus

5/5

Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - Influenza Infection (Homo sapiens)
      - Fusion and Uncoating of the Influenza Virion (Homo sapiens)
        
        Fusion of the Influenza Virion to the Host Cell Endosome (Homo sapiens)
        
        Conformation change in hemagglutinin freeing the fusion peptide of HA2 (Homo sapiens)

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Conformation change in hemagglutinin freeing the fusion peptide of HA2

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The low pH of the endosome causes the viral HA (hemagglutinin) to undergo a structural change which frees the fusion peptide of its HA2 subunit.

Literature References

PubMed ID	Title	Journal	Year
11208147	Membrane fusion mechanisms: the influenza hemagglutinin paradigm and its implications for intracellular fusion Stegmann, T	Traffic	2000

Participants

Input

Influenza A Viral Particle [endosome lumen] (Influenza A virus)

Output

Influenza A Viral Particle With A Fusion Competent HA2 [endosome lumen] (Influenza A virus)

Participates

as an event of

Fusion of the Influenza Virion to the Host Cell Endosome (Homo sapiens)

Disease

Name	Identifier	Synonyms
influenza	DOID:8469	Influenza with other manifestations (disorder), Influenza with other manifestations NOS (disorder), flu, Influenza with other manifestations, Influenza with non-respiratory manifestation (disorder), influenza with non-respiratory manifestation

Created

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