Reactome | Elongation, Polyadenylation and Termination

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Elongation, Polyadenylation and Termination

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authored	[InstanceEdit:193029] Bortz, E, Garcia-Sastre, A, 2007-02-12 19:39:05
catalystActivity	[CatalystActivity:192665] RNA-directed 5'-3' RNA polymerase activity of Viral Polymerase [nucleoplasm]
category	omitted
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:168327] 2007-04-16 22:35:07
dbId	168301
disease	[Disease:1660558] influenza
displayName	Elongation, Polyadenylation and Termination
eventOf	[Pathway:R-HSA-168325] Viral Messenger RNA Synthesis - Homo sapiens
followingEvent	[Reaction:R-HSA-192627] Viral mRNA Export - Homo sapiens [Reaction:R-HSA-192781] Viral mRNA Splicing (M, NS segments) - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:6686] viral transcription
input	[Complex:R-FLU-192756] Initiated vRNA Transcription Complex [nucleoplasm] [DefinedSet:R-ALL-30595] NTP [nucleoplasm]
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:192770] The polyadenylation signal of influenza virus RNA involves a stretch of uridines followed by the RNA duplex of the panhandle structure [LiteratureReference:192722] Polyadenylation sites for influenza virus mRNA [LiteratureReference:169028] Influenza A virus RNA polymerase has the ability to stutter at the polyadenylation site of a viral RNA template during RNA replication [LiteratureReference:192658] The RNA polymerase of influenza virus, bound to the 5' end of virion RNA, acts in cis to polyadenylate mRNA [LiteratureReference:169041] Influenza virion transcriptase: synthesis in vitro of large, polyadenylic acid-containing complementary RNA [LiteratureReference:192708] Molecular model of a eucaryotic transcription complex: functions and movements of influenza P proteins during capped RNA-primed transcription
modified	[InstanceEdit:9634280] Gillespie, Marc E, 2019-01-08
name	Elongation, Polyadenylation and Termination
output	[DefinedSet:R-FLU-192988] viral mRNA [nucleoplasm] [Complex:R-FLU-192720] Viral Polymerase [nucleoplasm] [Complex:R-FLU-193302] vRNA (Genomic):NP Complex [nucleoplasm]
precedingEvent	[Reaction:R-HSA-168280] Priming and Initiation of Transcription - Homo sapiens
relatedSpecies	[Species:9031716] Influenza A virus
releaseDate	2005-06-13
reviewed	[InstanceEdit:193030] Squires, B, 2007-02-12 19:39:22
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-168301
summation	[Summation:168983] Catalyzed by the RNA polymerase activity of the viral PB1 su...

Referrals

(precedingEvent)	[Reaction:R-HSA-192781] Viral mRNA Splicing (M, NS segments) - Homo sapiens [Reaction:R-HSA-192627] Viral mRNA Export - Homo sapiens
(hasEvent)	[Pathway:R-HSA-168325] Viral Messenger RNA Synthesis - Homo sapiens