Reactome | PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane

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PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane Show undefined attributes

authored	[InstanceEdit:1678579] Williams, MG, 2011-10-18
catalystActivity	[CatalystActivity:1806220] phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity of TPTE2-like proteins [Golgi membrane]
category	transition
compartment	[Compartment:20699] Golgi membrane [Compartment:70101] cytosol
created	[InstanceEdit:1676083] Williams, MG, 2011-10-17
dbId	1676204
displayName	PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane
edited	[InstanceEdit:1482514] Williams, MG, 2011-08-12
eventOf	[Pathway:R-HSA-1660514] Synthesis of PIPs at the Golgi membrane - Homo sapiens
followingEvent	[Reaction:R-HSA-1675928] PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A/G at the Golgi membrane - Homo sapiens [BlackBoxEvent:R-HSA-1675815] PI4P transports from the Golgi membrane to the plasma membrane - Homo sapiens [Reaction:R-HSA-1676133] PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane - Homo sapiens
input	[SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-1806230] PI(3,4)P2 [Golgi membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1676010] The TPTE gene family: cellular expression, subcellular localization and alternative splicing [LiteratureReference:1675798] TPIP: a novel phosphoinositide 3-phosphatase
maxDepth	1
modified	[InstanceEdit:11051501] Weiser, Joel, 2026-03-16
name	PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane
orthologousEvent	[Reaction:R-MMU-1676204] PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane - Mus musculus [Reaction:R-SPO-1676204] PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane - Schizosaccharomyces pombe [Reaction:R-DDI-1676204] PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane - Dictyostelium discoideum [Reaction:R-GGA-1676204] PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane - Gallus gallus [Reaction:R-XTR-1676204] PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane - Xenopus tropicalis [Reaction:R-DRE-1676204] PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane - Danio rerio [Reaction:R-SSC-1676204] PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane - Sus scrofa [Reaction:R-BTA-1676204] PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane - Bos taurus [Reaction:R-CFA-1676204] PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane - Canis familiaris [Reaction:R-RNO-1676204] PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane - Rattus norvegicus
output	[SimpleEntity:R-ALL-29372] Pi [cytosol] [SimpleEntity:R-ALL-1806217] PI4P [Golgi membrane]
precedingEvent	[Reaction:R-HSA-1675928] PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A/G at the Golgi membrane - Homo sapiens
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2247963] Wakelam, Michael, 2012-05-14
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1676204
summation	[Summation:1676094] At the Golgi membrane, phosphatidylinositol-3,4,5-trisphosph...

Referrals

(hasEvent)	[Pathway:R-HSA-1660514] Synthesis of PIPs at the Golgi membrane
(precedingEvent)	[BlackBoxEvent:R-HSA-1675815] PI4P transports from the Golgi membrane to the plasma membrane [Reaction:R-HSA-1676133] PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane [Reaction:R-HSA-1675928] PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A/G at the Golgi membrane