Reactome | PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane

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PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane Show undefined attributes

catalystActivity	[CatalystActivity:10381026] phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity of TPTE2-like proteins [Golgi membrane]
category	transition
compartment	[Compartment:20699] Golgi membrane [Compartment:70101] cytosol
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10381028
displayName	PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane
eventOf	[Pathway:R-BTA-1660514] Synthesis of PIPs at the Golgi membrane - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-BTA-1675928] PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A/G at the Golgi membrane - Bos taurus [Reaction:R-BTA-1676133] PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane - Bos taurus
inferredFrom	[Reaction:R-HSA-1676204] PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane - Homo sapiens
input	[SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-1806230] PI(3,4)P2 [Golgi membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane
output	[SimpleEntity:R-ALL-29372] Pi [cytosol] [SimpleEntity:R-ALL-1806217] PI4P [Golgi membrane]
precedingEvent	[Reaction:R-BTA-1675928] PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A/G at the Golgi membrane - Bos taurus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-1676204
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-1660514] Synthesis of PIPs at the Golgi membrane
(inferredTo)	[Reaction:R-HSA-1676204] PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane
(precedingEvent)	[Reaction:R-BTA-1675928] PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A/G at the Golgi membrane [Reaction:R-BTA-1676133] PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane

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