Phosphorylation of complexed TSC2 by PKB

Stable Identifier
R-HSA-165182
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Phosphorylation of TSC2 by PKB disrupts TSC1:TSC2 heterodimer formation (Hay & Sonenberg 2004) inducing ubiquination and degradation of both TSC1 and TSC2 through the proteosome pathway (Inoki et al. 2002, Dan et al. 2002, Proud 2002). Degradation of TSC2 is not always seen; dissociation of TSC2 from the lysosomal membrane has been suggested as an alternative mechanism (Menon et al. 2014).

Literature References
PubMed ID Title Journal Year
12869586 Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling

Inoki, K, Guan, KL, Li, Y, Xu, T

Genes Dev 2003
Participants
Participates
Catalyst Activity

protein serine/threonine kinase activity of p-T309,S474-AKT2:PIP3 [plasma membrane]

Orthologous Events
Authored
Reviewed
Created
Cite Us!