Phosphorylation of TSC2 by PKB disrupts TSC1:TSC2 heterodimer formation (Hay & Sonenberg 2004) inducing ubiquination and degradation of both TSC1 and TSC2 through the proteosome pathway (Inoki et al. 2002, Dan et al. 2002, Proud 2002). Degradation of TSC2 is not always seen; dissociation of TSC2 from the lysosomal membrane has been suggested as an alternative mechanism (Menon et al. 2014).