Phosphorylation of complexed TSC2 by PKB

Stable Identifier
R-HSA-165182
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Phosphorylation of TSC2 by PKB disrupts TSC1:TSC2 heterodimer formation (Hay & Sonenberg 2004) inducing ubiquination and degradation of both TSC1 and TSC2 through the proteosome pathway (Inoki et al. 2002, Dan et al. 2002, Proud 2002). Degradation of TSC2 is not always seen; dissociation of TSC2 from the lysosomal membrane has been suggested as an alternative mechanism (Menon et al. 2014).

Literature References
PubMed ID Title Journal Year
12869586 Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling

Inoki, K, Li, Y, Xu, T, Guan, KL

Genes Dev 2003
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of p-T309,S474-AKT2:PIP3 [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created